In Vivo Modification of Porin Activity Conferring Antibiotic Resistance to Enterobacter aerogenes
| Autor: | Jacqueline Chevalier, Monique Malléa, Jean-Marie Pagès |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Carbonyl Cyanide m-Chlorophenyl Hydrazone
medicine.drug_class Cefepime Cephalosporin Enterobacter Biophysics Porins Microbial Sensitivity Tests Enterobacter aerogenes Biochemistry Antibodies Membrane Potentials Microbiology Bacterial genetics Epitopes Antibiotic resistance medicine Molecular Biology Cephalosporin Resistance Antigens Bacterial Ionophores biology Cell Biology biology.organism_classification Cephalosporins Mutation Porin Antibacterial activity medicine.drug |
| Zdroj: | Biochemical and Biophysical Research Communications. 266:248-251 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.1999.1795 |
| Popis: | Cephalosporins are widely used in chemotherapy of bacterial infections and resistance mechanisms seriously impair their antibacterial activity. Several resistant strains of Enterobacter aerogenes, a frequently isolated nosocomial pathogen, were analyzed. One isolate exhibited a strong modification of the porin antigenic pattern, especially with an immunological probe directed against an epitope located inside the pore lumen. A strong decrease of cefepime uptake was evidenced for this isolate, similarly to ones observed for porin-deficient strains: these kinetics show a serious alteration of the channel properties which may support cephalosporin resistance. This is the first E. aerogenes isolate using such adaptive response which defines an original enterobacterial answer to cephalosporin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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