Connective Tissue
| Autor: | Nadhipuram V. Bhagavan, Chung-Eun Ha |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Materials science
Tropocollagen Mucopolysaccharidosis education Connective tissue Extracellular medicine health care economics and organizations chemistry.chemical_classification integumentary system biology Catabolism Chemistry Scleroprotein Ground substance Fibrillogenesis medicine.disease humanities Structure and function Cell biology body regions surgical procedures operative medicine.anatomical_structure Biochemistry Collagenase biology.protein Elastin medicine.drug |
| DOI: | 10.1016/b978-0-12-416687-5.00010-5 |
| Popis: | Connective tissue provides support and framework for the body. It consists of fibrous proteins and non-fibrous ground substance in varying proportions depending on their function. Collagens are extracellular proteins of connective tissue and they make up about one third of all body protein. The synthesis of collagen occurs in two stages: intracellular and extracellular. The intracellular stage consists of the production of procollagen from precursor polypeptide chains that undergo, in sequence, hydroxylation, glycosylation, formation of a triple helix, and secretion. The extracellular stage consists of the conversion of procollagen to tropocollagen by limited proteolysis from the amino and carboxyl termini, self-assembly of tropocollagen molecules into fibrils, and finally cross-linking of the fibrils to form collagen fibers. The catabolism of collagen in the connective tissue matrix is carried out by enzymes known as collagenases. The chapter describes the structure and function of elastin, which contains mostly nonpolar amino acids and it is insoluble. Types, structures, and functions of glycosaminoglycans are also discussed in the chapter. |
| Databáze: | OpenAIRE |
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