Fasting glucose level is associated with nocturnal hypoglycemia in elderly male patients with type 2 diabetes

Autor:	Jian Li, Fu-sheng Fang, Chunlin Li, Xiaoling Cheng, Hui Tian, Zhibing Li, Haiying Xiao
Rok vydání:	2013
Předmět:	Blood Glucose Male medicine.medical_specialty Pediatrics endocrine system diseases Type 2 diabetes Hypoglycemia Nocturnal hypoglycemia Fasting glucose Internal medicine Blood Glucose Self-Monitoring Diabetes mellitus medicine Humans Aged Aged 80 and over business.industry nutritional and metabolic diseases Fasting Middle Aged medicine.disease Endocrinology Diabetes Mellitus Type 2 ROC Curve Male patient Geriatrics and Gerontology business Biomarkers
Zdroj:	The Aging Male. 16:132-136
ISSN:	1473-0790 1368-5538
DOI:	10.3109/13685538.2013.818111
Popis:	Nocturnal hypoglycemia was a common and serious problem among patients with type 2 diabetes (T2DM), especially in the elderly. This study investigated whether fasting glucose was an indicator of nocturnal hypoglycemia in elderly male patients with T2DM.A total of 291 elderly male type 2 diabetic patients who received continuous glucose monitoring (CGM) between January 2007 and January 2011 were enrolled in the study. The association of fasting glucose and nocturnal hypoglycemia based on CGM data was analyzed, comparing with bedtime glucose.Based on CGM data, patients with nocturnal hypoglycemia had significantly lower fasting glucose (5.88 ± 1.29 versus 6.92 ± 1.32 mmol/L) and bedtime glucose (7.33 ± 1.70 versus 8.01 ± 1.95 mmol/L) than patients without nocturnal hypoglycemia (both p0.01). Compared with the highest quartile, the lowest quartile of fasting glucose had a significantly increased risk of nocturnal hypoglycemia after the multiple adjustments (pfor trend0.001). However, this association did not appear in bedtime glucose. When the prediction of nocturnal hypoglycemia either by fasting glucose or bedtime glucose using the area under receiver operating characteristic (ROC) curve, fasting glucose but not bedtime glucose, was an indicator of nocturnal hypoglycemia, with an area under the ROC curve (AUC) of 0.714 (95% CI: 0.653 ∼ 0.774, p0.001). On the ROC curve, the Youden index was maximal when fasting glucose was 6.1 mmol/L.Fasting glucose may be a convenient and clinically useful indicator of nocturnal hypoglycemia in elderly male patients with T2DM. Risk of nocturnal hypoglycemia significantly increased when fasting glucose was less than 6.1 mmol/L.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b92e1ed0613ee93ff2443faaaacc8940 https://doi.org/10.3109/13685538.2013.818111 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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