The Effect of Quinine on the Electroretinograms of Children with Pediatric Cerebral Malaria
| Autor: | Malcolm E. Molyneux, Terrie E. Taylor, Peter Winstanley, Benedetto Falsini, E.K. Mberu, Jonathan Lochhead, Simon P. Harding, Charles E. Riva, Armand Movaffaghy |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Time Factors genetic structures Malaria Cerebral Retina Antimalarials Retinal Diseases Electroretinography medicine Humans Immunology and Allergy Child Depression (differential diagnoses) Quinine medicine.diagnostic_test business.industry Settore MED/30 - MALATTIE APPARATO VISIVO Electroretinogram medicine.disease Infectious Diseases El Niño Cerebral Malaria Anesthesia Toxicity Linear Models Female sense organs business Erg Malaria medicine.drug |
| Zdroj: | The Journal of Infectious Diseases. 187:1342-1345 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/374058 |
| Popis: | To investigate the effects of quinine on the electroretinograms (ERGs) of children with cerebral malaria (CM), we recruited subjects during a single malaria season in Blantyre, Malawi. Seventy ERG investigations were performed, on 34 children with CM. Time recorded from completion of the most recent quinine infusion was termed quinine elapsed time (QET). In a subgroup of 16 children, whole-blood quinine concentrations were estimated in a sample of capillary blood, for validation. A significant positive association was found between QET and both maximal-response A-wave amplitude (MRAWA; P = .03) and cone A-wave amplitude (P = .04). Longitudinal analysis demonstrated a significant trend of increasing MRAWA with increasing QET (P = .03). Parenteral quinine administered in therapeutic doses to a pediatric population appears to cause a transient depression in photoreceptor function. No evidence of ocular quinine toxicity was found at the therapeutic doses used. |
| Databáze: | OpenAIRE |
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