Cost-minimization analysis of sublingual immunotherapy versus subcutaneous immunotherapy for house dust mite respiratory allergic disease in Denmark
Autor: | Anders Winther, Jakob Nørgaard Andreasen, Steen Meier Ronborg, Sune Theilgaard, Claus R. Johnsen, Julie Hahn-Pedersen, Jens Olsen |
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Rok vydání: | 2016 |
Předmět: |
Allergy
medicine.medical_specialty Denmark Injections Subcutaneous Disease 03 medical and health sciences Indirect costs 0302 clinical medicine Internal medicine Subcutaneous immunotherapy Animals Humans Medicine Sublingual immunotherapy 030212 general & internal medicine House dust mite Sublingual Immunotherapy biology business.industry Health Policy Pyroglyphidae medicine.disease biology.organism_classification Rhinitis Allergic eye diseases 030228 respiratory system Desensitization Immunologic Cost-minimization analysis Immunology Costs and Cost Analysis business Models Econometric |
Zdroj: | Journal of Medical Economics. 19:735-741 |
ISSN: | 1941-837X 1369-6998 |
Popis: | Objectives Currently, patients with persistent moderate-to-severe house dust mite (HDM) allergic rhinitis despite use of symptom-relieving medication can be offered subcutaneously administered allergy immunotherapy (SQ SCIT; Alutard SQ) as standard care of treatment in Denmark. Recently, a HDM sublingually administered allergy immunotherapy tablet (SQ SLIT-tablet; ACARIZAX) has been developed for at-home treatment. The purpose of this analysis is to compare the costs related to treatment and administration of SQ SLIT-tablet and SQ SCIT. Methods Assuming equal efficacy between ther SQ SLIT-tablet and SQ SCIT, the cost-minimization analysis was the most appropriate for the comparison. According to guidelines and Summary of Product Characteristics, the treatment duration of SQ SLIT-tablet is 3 years and 3-5 years for SQ SCIT. The courses of treatment vary among patients and, therefore, the costs of treatment have been calculated for an average patient with HDM respiratory allergic disease (RAD) receiving either SQ SLIT-tablet or SQ SCIT. All costs associated with allergy immunotherapy were collected, i.e., cost of medication, administration and treatment setting, and discounted according to Danish guidelines. Comprehensive univariate sensitivity analyses were carried out. Results The treatment costs for an average patient with HDM RAD are €3094 for SQ SLIT-tablet and €3799 for SQ SCIT; however, when adding indirect costs to the calculations the total costs of the treatments are €3697 and €6717 for SQ SLIT-tablet and SQ SCIT, respectively. Therefore, if 2500 patients with HDM RAD were treated with SQ SLIT-tablet instead of SQ SCIT, it would elicit a saving to the healthcare system of ∼€1.8 million. The conclusion was robust to any changes in the sensitivity analysis. Conclusion With regards to the cost of treating Danish patients with HDM RAD, it is clearly cost-saving to treat patients with SQ SLIT-tablet compared to SQ SCIT. |
Databáze: | OpenAIRE |
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