Genetic association study of tumor necrosis factor-alpha with sepsis and septic shock in Thai pediatric patients
| Autor: | Nunthawut Chat-Uthai, Vip Viprakasit, Suwannee Phumeetham, Manutham Manavathongchai |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Pathology Adolescent Genotype Population Single-nucleotide polymorphism Sepsis Asian People Gene Frequency Immunopathology Internal medicine Intensive care medicine SNP Humans education Child Genetic association education.field_of_study Polymorphism Genetic Septic shock business.industry Tumor Necrosis Factor-alpha Infant Newborn Infant medicine.disease Thailand Shock Septic Child Preschool Pediatrics Perinatology and Child Health business Epidemiologic Methods |
| Zdroj: | Jornal de pediatria. 88(5) |
| ISSN: | 1678-4782 |
| Popis: | Objectives: To evaluate the association between the genetic polymorphism of the tumor necrosis factor-alpha (TNF-α) gene and the development of sepsis and septic shock in Thai pediatric patients and to investigate the clinical impacts of TNF-α polymorphisms in this population. Methods: To perform this genetic association study, a prospective analysis of pediatric patients (age < 18 years) with clinical sepsis/septic shock was conducted. All clinical data were collected by pediatric intensive care experts, and genetic analyses were performed at a central laboratory. A single nucleotide polymorphism (SNP) located in the 5’-promoter region at position -308 was genotyped and the results were associated with clinical phenotypes. Results: A total of 167 Thai individuals were investigated, 66 of which were pediatric patients with sepsis/ septic shock and 101 were healthy controls. Interestingly, we could not identify an association between sepsis and -308 (G/A) polymorphism, which have previously been demonstrated to be a major SNP associated with sepsis in several Caucasian populations, since there was no frequency difference between cases and controls. Conclusions: In this report, the major TNF-α polymorphism (-308) was not associated with clinical sepsis/ septic shock in Thais. This information will be important for future analyses to identify the role of TNF-α as a genetic risk for the development of immunopathology underlying several diseases in Asia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|