Complete urological evaluation including sperm DNA fragmentation in male systemic lupus erythematosus patients
| Autor: | Bruno Camargo Tiseo, Eloisa Bonfa, Guilherme J. A. Wood, G. A. Munhoz, Clovis A. Silva, M Cocuzza, Miguel Srougi, Eduardo Ferreira Borba |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 030203 arthritis & rheumatology 030219 obstetrics & reproductive medicine business.industry DNA Fragmentation Middle Aged Severity of Illness Index Spermatozoa Sperm Semen Analysis Young Adult 03 medical and health sciences 0302 clinical medicine Rheumatology Case-Control Studies Immunology Humans Lupus Erythematosus Systemic Medicine DNA fragmentation Prospective Studies business Cyclophosphamide Hormone |
| Zdroj: | Lupus. 28:59-65 |
| ISSN: | 1477-0962 0961-2033 |
| DOI: | 10.1177/0961203318815764 |
| Popis: | Objective To evaluate sperm DNA fragmentation analysis in non-azoospermic male systemic lupus erythematosus (SLE) patients. Methods Twenty-eight consecutive male SLE patients (American College of Rheumatology criteria) and 34 healthy controls were evaluated for demographic/exposures data, urological evaluation, hormone profile and sperm analysis (including sperm DNA fragmentation). Clinical features, disease activity/damage scores and treatment were also evaluated. Results The median age (33 (20–52) vs. 36.5 (25–54) years, P = 0.329) and frequency of varicocele (25% vs. 32%, P = 0.183) were similar in SLE patients and healthy controls. Sperm DNA fragmentation showed significantly higher levels of cells class III (44 (9–88) vs. 16.5 (0–80)%, P = 0.001) and cell class IV (10.5 (3–86) vs. 7 (0–36)%, P = 0.039) in SLE. The sperm DNA fragmentation index was also significantly higher in SLE patients (62 (31–97) vs. 25.5 (0–100)%, P 0.05). Further analysis of SLE patients treated with and without intravenous cyclophosphamide showed that total sperm motility was significantly lower in the former group (64% (15–83) vs. 72% (57–86), P = 0.024). The sperm DNA fragmentation index was alike in both groups (52.5 (31–95) vs. 67.5 (34–97)%, P = 0.185). Conclusions To our knowledge, this is the first demonstration that male non-azoospermic SLE patients have increased sperm DNA fragmentation without evident gonadal dysfunction. Intravenous cyclophosphamide does not seem to be a major determinant for this abnormality. Future prospective study is necessary to determine the impact of this alteration in these patients' fertility. |
| Databáze: | OpenAIRE |
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