To compare CSF adenosine deaminase levels and CSF-PCR for tuberculous meningitis
| Autor: | S. K. Arora, F. Chacko, Kulwinder Singh, S. Parbhakar, Vivek Lal, Sanjeev Sharma, S. V. Rana |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Time Factors Tuberculosis Fever Adenosine Deaminase urologic and male genital diseases Polymerase Chain Reaction Sensitivity and Specificity Tuberculous meningitis law.invention Mycobacterium tuberculosis Cerebrospinal fluid Adenosine deaminase law medicine Humans Polymerase chain reaction DNA Primers medicine.diagnostic_test biology business.industry General Medicine medicine.disease biology.organism_classification Tuberculosis Meningeal Erythrocyte sedimentation rate Immunology biology.protein Female Surgery Neurology (clinical) business Meningitis |
| Zdroj: | Clinical Neurology and Neurosurgery. 112:424-430 |
| ISSN: | 0303-8467 |
| Popis: | This study was planned to compare the adenosine deaminase (ADA) levels and polymerase chain reaction (PCR) in cerebrospinal fluid (CSF) as a rapid method to diagnose tuberculosis meningitis (TBM). Fifty-four adult patients with suspected TBM and 37 controls were included in this study. The median ADA level was 21U/L of most likely TBM, 14U/L of unconfirmed TBM and 5U/L of controls. PCR for Mycobacterium tuberculosis was positive in 12 out of 27 most likely TBM cases, 5 out of 27 unconfirmed TBM cases and 3 out of 37 controls. Using a cut off level of >10U/L, CSF-ADA had a sensitivity of 92.5% and specificity of 97% for the diagnosis of TBM. PCR for M. tuberculosis had a sensitivity of 44.5% and specificity 92% in the most likely TBM cases. This study shows that CSF-ADA is a more sensitive indicator than PCR for the diagnosis of M. tuberculosis. |
| Databáze: | OpenAIRE |
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