Nanocarbon Allotropes-Graphene and Nanocrystalline Diamond-Promote Cell Proliferation
| Autor: | Martin Kalbac, Alexander Kromka, Oleg Babchenko, Marie Hubalek Kalbacova, Antonin Broz, Egor Ukraintsev, Martina Verdanova, Tibor Izak, Bohuslav Rezek, Anna Artemenko |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Scanning electron microscope Nanoparticle Nanotechnology 02 engineering and technology engineering.material Microscopy Atomic Force 010402 general chemistry 01 natural sciences law.invention Biomaterials Contact angle symbols.namesake X-ray photoelectron spectroscopy law Humans General Materials Science Graphite Cells Cultured Cell Proliferation Graphene Photoelectron Spectroscopy Stem Cells Diamond General Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences Microscopy Electron Scanning engineering symbols Nanoparticles 0210 nano-technology Raman spectroscopy Biotechnology |
| Zdroj: | Small. 12:2499-2509 |
| ISSN: | 1613-6810 |
| Popis: | Two profoundly different carbon allotropes - nanocrystalline diamond and graphene - are of considerable interest from the viewpoint of a wide range of biomedical applications including implant coating, drug and gene delivery, cancer therapy, and biosensing. Osteoblast adhesion and proliferation on nanocrystalline diamond and graphene are compared under various conditions such as differences in wettability, topography, and the presence or absence of protein interlayers between cells and the substrate. The materials are characterized in detail by means of scanning electron microscopy, atomic force microscopy, photoelectron spectroscopy, Raman spectroscopy, and contact angle measurements. In vitro experiments have revealed a significantly higher degree of cell proliferation on graphene than on nanocrystalline diamond and a tissue culture polystyrene control material. Proliferation is promoted, in particular, by hydrophobic graphene with a large number of nanoscale wrinkles independent of the presence of a protein interlayer, i.e., substrate fouling is not a problematic issue in this respect. Nanowrinkled hydrophobic graphene, thus, exhibits superior characteristics for those biomedical applications where high cell proliferation is required under differing conditions. |
| Databáze: | OpenAIRE |
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