Race Does Not Affect Tumor Control, Adverse Effects, or Quality of Life after Proton Therapy
| Autor: | Christopher G. Morris, William M. Mendenhall, Curtis Bryant, Tamara L Smith, Randal H. Henderson, Zuofeng Li, Zhong Su, Nancy P. Mendenhall, Romaine C. Nichols, Christopher R. Williams, Bradford S. Hoppe |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Multivariate analysis business.industry Genitourinary system Medical record Original Articles medicine.disease Atomic and Molecular Physics and Optics Surgery 03 medical and health sciences Prostate cancer 030104 developmental biology 0302 clinical medicine Quality of life 030220 oncology & carcinogenesis Internal medicine Toxicity medicine Radiology Nuclear Medicine and imaging business Adverse effect Proton therapy |
| Zdroj: | International Journal of Particle Therapy. 3:461-472 |
| ISSN: | 2331-5180 |
| DOI: | 10.14338/ijpt-17-00006 |
| Popis: | PURPOSE: To compare 5-year biochemical control, toxicity, and patient-reported quality of life (QOL) outcomes for African American and White patients treated with proton therapy (PT) for prostate cancer. MATERIALS AND METHODS: We reviewed the medical records of 1,066 men with clinically localized prostate cancer. Patients were treated with definitive PT between 2006 and 2010. Patients received a median radiation dose of 78 Gy (RBE) with conventional fractionation (1.8- 2 Gy [RBE] per fraction). Sixty-eight (6.4%) men self-identified as African American and 998 (93.6%) self-identified as White. Five-year rates of biochemical control, grade 3 genitourinary and gastrointestinal toxicity, and patient-reported QOL are reported and compared between African American and White patients. RESULTS: Median biochemical follow-up was 5.0 years for both African American and White patients. Median follow-up for toxicity was 5.0 and 5.2 years, respectively. On multivariate analysis, race was not a significant predictor for 5-year freedom from biochemical failure (HR 0.8, p=0.55). No significant association was found between race and grade 3 genitourinary toxicity on multivariate analysis at 5 years (HR 2.5, p=0.10). Patient-reported QOL using median EPIC bowel, urinary incontinence, and irritative summaries scores were not significantly different between the groups. African Americans had higher median sexual summary scores at 2 years than White patients (75 vs. 54, p=0.01) but by 5+ years, the sexual summary scores were no longer significantly different (63 vs. 53, p=0.35). CONCLUSION: With a median follow-up of 5 years, there were no racial disparities in biochemical control, grade 3 toxicity, or patient-reported QOL after PT for prostate cancer. |
| Databáze: | OpenAIRE |
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