| Popis: |
Perceived discrimination may be associated with accelerated aging later in life, with depressive symptoms acting as potential mediator.A nationally representative sample of older adults was used [Health and Retirement Study 2010-2016, Age: 50-100 y in 2016,Overall, and mostly among female and NHW participants, greater RPD in 2010-2012 had a significant adverse total effect on epigenetic aging [2016: DNAm GrimAge, DunedinPoAm38 (MPOA), Levine (PhenoAge) and Horvath 2], with 20-50% of this effect being explained by a pure indirect effect through DEP in 2014-2016. Among females, sustained elevated DEP (2010-2016) was associated with greater LIN DNAm age (β ± SE: +1.506 ± 0.559,Sustained elevations in DEP and RPD were associated with select biological aging measures, consistently among women and White adults, with DEP acting as mediator in several RPD-EPICLOCK associations. |
