Metabolic reprogramming following a combined treatment with imipridones and 2-deoxyglucose elicits energy depletion and synergistic anti-glioblastoma activity

Autor:	Pruss, M, Dwucet, A, Westhoff, MA, Hlavac, M, Siegelin, MD, Wirtz, CR, Halatsch, ME, Karpel-Massler, G
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	ddc: 610 610 Medical sciences Medicine
Zdroj:	70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie; 20190512-20190515; Würzburg; DOCP054 /20190508/
DOI:	10.3205/19dgnc392
Popis:	Objective: The purpose of this study was to examine whether dual reprogramming of the metabolome of glioblastoma cells by imipridone-mediated OXPHOS inhibition and 2-deoxyglucose-mediated inhibition of glycolysis leads to enhanced anti-cancer activity. Methods: Preclinical drug testing including[for full text, please go to the a.m. URL] 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91f5d7bb427a92673e611ea034331f5 Zobrazit plný text záznamu