Antihyperglycemic and antihyperlipidemic activities of Nannochloropsis oculata microalgae in Streptozotocin-induced diabetic rats
| Autor: | Hadi Sarir, Nasroallah Moradi-Kor, Fariba Nasirian |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine insulin QH301-705.5 medicine.medical_treatment Administration Oral Pharmacology Body weight nannochloropsis microalgae General Biochemistry Genetics and Molecular Biology Diabetes Mellitus Experimental 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound Oral administration Diabetes mellitus Microalgae medicine Animals Hypoglycemic Agents Nannochloropsis oculata diabetic rat Rats Wistar glucose Biology (General) Hypolipidemic Agents 030109 nutrition & dietetics Plant Extracts Cholesterol Insulin General Medicine Weight control medicine.disease Streptozotocin Rats healthy rat 030104 developmental biology chemistry medicine.drug |
| Zdroj: | Biomolecular Concepts, Vol 10, Iss 1, Pp 37-43 (2019) |
| ISSN: | 1868-5021 |
| Popis: | BackgroundIt is well documented that biologically active components of microalgae can be utilized for treatment of different diseases. This study was conducted to evaluate the antihyperglycemic and antihyperlipidemic activities and weight control ofNannochloropsis oculatamicroalgae (NOM) in Streptozotocin-induced diabetic male rats.MethodsDiabetes was induced by intraperitoneal administration of Streptozotocin (55 mg/kg). Healthy and diabetic rats were divided in to six groups. Healthy and diabetic rats orally received distilled water or NOM (10 and 20 mg/kg) for three weeks.ResultsOral administration of NOM to diabetic rats significantly reduced the serum concentrations of glucose, cholesterol, triglycerides, LDL and increased the serum concentration of insulin and HDL-C (PP>0.05). Also, NOM maintained body weight in diabetic rats (PConclusionIt can be concluded that NOM has antihyperglycemic and antihyperlipidemic activities in diabetic rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|