Translating animal model research: does it matter that our rodents are cold?
| Autor: | Shane K. Maloney, Christopher J. Gordon, Duncan Mitchell, J. Michael Overton, Andrea Fuller |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pathology
medicine.medical_specialty Genotype Physiology Longevity Energy metabolism Biology Cardiovascular Physiological Phenomena Translational Research Biomedical Mice Animal model Species Specificity medicine Animals Humans Cold-Shock Response Environment Controlled Housing Animal Cold shock response Rats Cold Temperature Phenotype Models Animal Energy Metabolism Body Temperature Regulation |
| Zdroj: | Physiology (Bethesda, Md.). 29(6) |
| ISSN: | 1548-9221 |
| Popis: | Does it matter that rodents used as preclinical models of human biology are routinely housed below their thermoneutral zone? We compile evidence showing that such rodents are cold-stressed, hypermetabolic, hypertensive, sleep-deprived, obesity-resistant, fever-resistant, aging-resistant, and tumor-prone compared with mice housed at thermoneutrality. The same genotype of mouse has a very different phenotype and response to physiological or pharmacological intervention when raised below or at thermoneutrality. |
| Databáze: | OpenAIRE |
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