HEPATIC AND INTESTINAL CHANGES IN RATS TREATED WITH T-0126, A MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) INHIBITOR
| Autor: | Satoko Miwa, Koichi Nagata, Miyazaki, Harutami Yamada, Eisuke Kume, Hirohiko Kodama, Kazuyuki Kitamura, Wataru Toriumi |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Indoles Malabsorption Administration Oral Mechanism based Blood lipids Vitamin k Toxicology Microsomal triglyceride transfer protein Fat accumulation Microsomes Internal medicine Intestine Small medicine Animals Cytotoxicity Hematologic Tests Dose-Response Relationship Drug biology Rats Inbred Strains Organ Size medicine.disease Lipids Small intestine Rats Endocrinology medicine.anatomical_structure Liver Chemistry Clinical Benzamides Hepatocytes biology.protein Female Lymph Nodes Carrier Proteins |
| Zdroj: | The Journal of Toxicological Sciences. 32:161-177 |
| ISSN: | 1880-3989 0388-1350 |
| DOI: | 10.2131/jts.32.161 |
| Popis: | In the present study, we investigated the potential toxic effects of 2-week oral treatment with T-0126, a novel microsomal triglyceride transfer protein (MTP) inhibitor, on the liver and intestine in male and female rats. Administration of T-0126 decreased serum lipids and resulted in fat accumulation in the liver and the small intestine. In addition, slight changes in the liver, including an increase in serum aminotransferase (AST and ALT) activity, presence of focal inflammatory lesions, and prolongation of PT and APTT were observed after treatment with T-0126. These changes may be related to a mechanism based on malabsorption of fat, fat-soluble antioxidants, and vitamin K, although we cannot exclude other potential mechanisms such as direct cytotoxicity of T-0126. |
| Databáze: | OpenAIRE |
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