Inhibition of interleukin 1 (IL-1)-elicited leukocytosis and LPS-induced fever by soluble immune response suppresor (SIRS)
| Autor: | Michał Zimecki, H. William Schnaper, C W Pierce, David R. Webb, Zbigniew Wieczorek |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Fever Lipopolysaccharide Leukocytosis Neutrophils Bone Marrow Cells Leukocyte Count Mice chemistry.chemical_compound Immune system Bone Marrow Oral administration Internal medicine Suppressor Factors Immunologic medicine Animals Antipyretic Pharmacology Aspirin business.industry Polysaccharides Bacterial Lymphokine Interleukin humanities Endocrinology chemistry Mice Inbred CBA Female Rabbits medicine.symptom business Interleukin-1 medicine.drug |
| Zdroj: | Immunopharmacology. 19:39-46 |
| ISSN: | 0162-3109 |
| DOI: | 10.1016/0162-3109(90)90025-a |
| Popis: | IL-1-induced leukocytosis was inhibited or blocked in a dose-dependent manner by SIRS, an antigen-nonspecific suppressive lymphokine, when administered intravenously or per os to CBA mice. Timing experiments showed that SIRS effectively inhibited the leukocytosis when administered within 30 minutes of the IL-1. An antipyrogenic activity of SIRS was observed in rabbits injected intravenously with LPS. SIRS, given intravenously in one or two doses, markedly reduced LPS-induced fever. SIRS (2000 units) was a more effective antipyretic agent than aspirin (3 mg/kg body weight, intramuscularly). The results suggest that SIRS may be a potential drug for use in IL-1-mediated disorders. |
| Databáze: | OpenAIRE |
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