Prospective Study of Serial 18F-FDG PET and 18F-Fluoride PET to Predict Time to Skeletal-Related Events, Time to Progression, and Survival in Patients with Bone-Dominant Metastatic Breast Cancer
| Autor: | David A. Mankoff, Vijayakrishna K. Gadi, Mark Muzi, Isaac C. Jenkins, Alena Novakova-Jiresova, Janet O'Sullivan, Qian Vicky Wu, Susan Montgomery, Paul E. Kinahan, Andrew Shields, Jean H. Lee, Julie R. Gralow, Lanell M. Peterson, Jennifer M. Specht, Hannah M. Linden |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Fluorine Radioisotopes Bone Neoplasms Breast Neoplasms Standardized uptake value Kaplan-Meier Estimate 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Breast cancer Fluorodeoxyglucose F18 medicine Clinical endpoint Humans Radiology Nuclear Medicine and imaging Prospective Studies neoplasms Survival analysis Aged Proportional Hazards Models Aged 80 and over PET-CT business.industry Bone metastasis Middle Aged medicine.disease Metastatic breast cancer Oncology Positron-Emission Tomography 030220 oncology & carcinogenesis Disease Progression Female Radiopharmaceuticals business Nuclear medicine Progressive disease |
| Zdroj: | Journal of Nuclear Medicine. 59:1823-1830 |
| ISSN: | 2159-662X 0161-5505 |
| DOI: | 10.2967/jnumed.118.211102 |
| Popis: | Assessing therapy response of breast cancer bone metastases is challenging. In retrospective studies, serial (18)F-FDG PET was predictive of time to skeletal-related events (tSRE) and time to progression (TTP). (18)F-NaF PET improves bone metastasis detection compared with bone scanning. We prospectively tested (18)F-FDG PET and (18)F-NaF PET to predict tSRE, TTP, and overall survival (OS) in patients with bone-dominant metastatic breast cancer (MBC). Methods: Patients with bone-dominant MBC were imaged with (18)F-FDG PET and (18)F-NaF PET before starting new therapy (scan1) and again at a range of times centered around approximately 4 mo later (scan2). Maximum standardized uptake value (SUV(max)) and lean body mass adjusted standardized uptake (SUL(peak)) were recorded for a single index lesion and up to 5 most dominant lesions for each scan. tSRE, TTP, and OS were assessed exclusive of the PET images. Univariate Cox regression was performed to test the association between clinical endpoints and (18)F-FDG PET and (18)F-NaF PET measures. mPERCIST (Modified PET Response Criteria in Solid Tumors) were also applied. Survival curves for mPERCIST compared response categories of complete response+partial response+stable disease versus progressive disease for tSRE, TTP, and OS. Results: Twenty-eight patients were evaluated. Higher (18)F-FDG SUL(peak) at scan2 predicted shorter time to tSRE (P = |
| Databáze: | OpenAIRE |
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