Platelet Activation and Inflammation in Patients with Papillary Thyroid Cancer
| Autor: | Cosmin Giulea, Simona Fica, Oana Enache, Anca Sirbu, Theodor Mustata, Sorina Martin, Andreea Chifulescu, Oana Ion, Carmen Barbu, A Miron, Florin Andrei |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Medicine (General) endocrine system diseases medicine.medical_treatment Clinical Biochemistry differentiated thyroid cancer Fibrinogen Gastroenterology Article Papillary thyroid cancer R5-920 Internal medicine Medicine Platelet papillary thyroid cancer Platelet activation Mean platelet volume medicine.diagnostic_test business.industry Thyroid Thyroidectomy medicine.disease inflammatory markers medicine.anatomical_structure Erythrocyte sedimentation rate business platelet indices medicine.drug |
| Zdroj: | Diagnostics, Vol 11, Iss 1959, p 1959 (2021) Diagnostics Volume 11 Issue 11 |
| ISSN: | 2075-4418 |
| Popis: | Background: The primary endpoint was to analyze the preoperatory inflammatory markers and platelet indices in papillary thyroid cancer (PTC) patients compared with patients with benign thyroid pathology. The secondary endpoints were to analyze the relationship between these markers and the pathological features of PTC and to compare their pre- and postoperative levels in PTC patients. Methods: In this retrospective case-control study, we analyzed the files of 1183 patients submitted to thyroidectomy between January 2012 and December 2018. A total of 234 patients with PTC (mean age 51.54 ± 13.10 years, 84.6% females) were compared with an age-, gender- and BMI-matched control group of 108 patients with histologic benign thyroid disorders. Results: PTC patients had higher platelet count (PLT) (p = 0.011), plateletcrit (PCT) (p = 0.006), neutrophil (p = 0.022) and fibrinogen (p = 0.005) levels. Subgroup analysis showed that PTC females had higher PLT (p = 0.006), PCT (p < 0.001) and erythrocyte sedimentation rate (ESR) (p = 0.005), while males had higher neutrophil (p = 0.040) levels. Papillary thyroid cancer patients under 55 years had higher PLT (p < 0.001) and PCT (p = 0.010), while patients over 55 years had higher mean platelet volume (p = 0.032), neutrophil-to-lymphocyte ratio (p = 0.013), ESR (p = 0.005) and fibrinogen (p = 0.019) levels. Preoperative values for platelet indices and inflammatory markers were similar to the postoperative determinations in PTC patients. Fibrinogen (AUROC = 0.602, p = 0.02 cut-off = 327.5 mg/dL, Se = 53.8%, Sp = 62.9%) and PLT (AUROC = 0.584, p = 0.012 cut-off = 223.5 × 103/mm3, Se = 73.1%, Sp = 42.6%) were independent predictors of the presence of PTC. Conclusions: Our data show that fibrinogen and platelet count could be promising, inexpensive, independent predictors for the presence of PTC when compared with benign thyroid disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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