Mitochondrial complex II and reactive oxygen species in disease and therapy
| Autor: | Katerina Vanova, Michal Kraus, Jakub Rohlena, Jiri Neuzil |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
Mitochondrial Diseases Physiology Clinical Biochemistry Review Article macromolecular substances Disease Oxidative phosphorylation Mitochondrion Biochemistry Electron Transport lcsh:Pathology medicine cancer Animals Humans Molecular Targeted Therapy Mitochondrial Complex II skin and connective tissue diseases lcsh:QH301-705.5 reactive oxygen species chemistry.chemical_classification Reactive oxygen species integumentary system Electron Transport Complex II Biochemistry (medical) Cancer Cell Biology succinate dehydrogenase succinate Respiratory complex II medicine.disease OXPHOS Mitochondria Citric acid cycle lcsh:Biology (General) chemistry tricarboxylic acid cycle Cancer research lcsh:RB1-214 |
| Zdroj: | Redox Report : Communications in Free Radical Research Redox Report, Vol 25, Iss 1, Pp 26-32 (2020) |
| ISSN: | 1743-2928 1351-0002 |
| Popis: | Increasing evidence points to the respiratory Complex II (CII) as a source and modulator of reactive oxygen species (ROS). Both functional loss of CII as well as its pharmacological inhibition can lead to ROS generation in cells, with a relevant impact on the development of pathophysiological conditions, i.e. cancer and neurodegenerative diseases. While the basic framework of CII involvement in ROS production has been defined, the fine details still await clarification. It is important to resolve these aspects to fully understand the role of CII in pathology and to explore its therapeutic potential in cancer and other diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |