Importance of Timing First-Trimester Placental Growth Factor and Use of Serial First-Trimester Placental Growth Factor Measurements in Screening for Preeclampsia
| Autor: | Beatrice Mosimann, Luigi Raio, Lorenz Risch, Daniel Surbek, Katrin Höland, Sofia Amylidi-Mohr |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Placental growth factor
Adult Embryology medicine.medical_specialty Gestational Age 610 Medicine & health Sensitivity and Specificity Preeclampsia 03 medical and health sciences 0302 clinical medicine Pre-Eclampsia Pregnancy Medicine Humans Mass Screening Radiology Nuclear Medicine and imaging 030212 general & internal medicine Longitudinal Studies Prospective Studies reproductive and urinary physiology Placenta Growth Factor 030219 obstetrics & reproductive medicine business.industry Obstetrics Obstetrics and Gynecology General Medicine medicine.disease female genital diseases and pregnancy complications First trimester Pregnancy Trimester First Prenatal screening Cross-Sectional Studies Pregnancy Trimester Second Pediatrics Perinatology and Child Health Female business Biomarkers |
| Zdroj: | Mosimann, Beatrice; Amylidi-Mohr, Sofia; Höland, Katrin; Surbek, Daniel; Risch, Lorenz; Raio, Luigi (2017). Importance of Timing First-Trimester Placental Growth Factor and Use of Serial First-Trimester Placental Growth Factor Measurements in Screening for Preeclampsia. Fetal diagnosis and therapy, 42(2), pp. 111-116. Karger 10.1159/000455946 |
| DOI: | 10.1159/000455946 |
| Popis: | Objective: The aims of this study were to test whether the performance of first-trimester placental growth factor (PlGF) in screening for preterm preeclampsia (PE) is gestational age dependent and to assess the value of serial first-trimester PlGF measurements in discriminating women at risk for PE. Methods: PlGF was measured in women with singleton pregnancies at their first antenatal visit at 8+0 to 10+6 and additionally at 11+0 to 14+0 weeks of gestation. The difference in absolute values of serial PlGF measurements was expressed as Δ-PlGF. Values were compared between pregnancies with normal outcome and those complicated by PE. Results: A total of 814 pregnancies were included, 18 (2.19%) developed PE that required delivery before 37 weeks of gestation. PlGF increases significantly from 8 to 14 weeks of gestation (ρ = 0.63; p < 0.0001) in normal pregnancies, but not so in preterm PE (ρ = 0.034; p = 0.893). PlGF discriminates between PE and uneventful pregnancies only after 10 weeks of gestation. Δ-PlGF was significantly lower in PE 5.3 (-1.1 to 9.3) pg/mL compared to uneventful pregnancies 17.3 (9.8-26.0) pg/mL (p = 0.0011). Conclusion: The discriminatory accuracy of PlGF increases from 10 to 14 weeks of gestation, and serial PlGF measurements might be of particular interest in PE screening. |
| Databáze: | OpenAIRE |
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