Co-expression of ras p21 and epidermal growth factor receptor during various stages of tumour progression in oral mucosa
| Autor: | Prabha Balaram, M. Radhakrishna Pillai, M. Krishnan Nair, S. Kannan, Beela Sarah Mathew, G. Jagadeesh Chandran |
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| Rok vydání: | 1994 |
| Předmět: |
Pathology
medicine.medical_specialty Epithelioma Mouth Mucosa Gene Expression General Medicine Biology medicine.disease_cause medicine.disease Immunohistochemistry ErbB Receptors Proto-Oncogene Proteins p21(ras) Basal (phylogenetics) medicine.anatomical_structure Epidermal growth factor medicine Carcinoma Cancer research biology.protein Humans Mouth Neoplasms Epidermal growth factor receptor Oral mucosa Carcinogenesis |
| Zdroj: | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 15(2) |
| ISSN: | 1010-4283 |
| Popis: | Ras p21 and epidermal growth factor receptor (EGFR) have commonly been implicated in a variety of malignancies. The present study immunohistochemically analysed the relationship between the expression of ras p21 and EGFR in normal, premalignant and malignant lesions of the oral mucosa. Except for normal mucosa, all other lesions showed a more or less similar expression pattern of both ras p21 and EGFR. It was also observed that the expression of both proteins was mostly confined to the basal or basaloid cells of the leucoplakia and carcinoma lesions, respectively. Normal keratinizing type mucosa showed expression of ras p21 and EGFR in the basal and lower spinal cells. However, in non-keratinizing mucosa the expression of ras p21 was totally negative while EGFR was restricted to the basal cells. Statistical analysis revealed a good correlation between the expression of ras p21 and EGFR with the various histological stages of tumour progression. The presence of these proteins in immature dividing cells of premalignant and malignant lesions thus emphasizes their relationship with cell proliferation. |
| Databáze: | OpenAIRE |
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