Case Report: Alagille Syndrome Presenting with Angioid Streaks
| Autor: | Konstantinos F Katsoulos, Gerasimos Livir-Rallatos, Zoi Kapsala |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Vascular Endothelial Growth Factor A medicine.medical_specialty genetic structures Angiogenesis Inhibitors 03 medical and health sciences 0302 clinical medicine Ranibizumab Alagille syndrome Humans Medicine Fluorescein Angiography Macular scar business.industry medicine.disease Dermatology Choroidal Neovascularization eye diseases Alagille Syndrome Ophthalmology Left eye Angioid streaks Choroidal neovascularization Intravitreal Injections 030221 ophthalmology & optometry Angioid Streaks Female sense organs medicine.symptom business Complication Tomography Optical Coherence 030217 neurology & neurosurgery Optometry medicine.drug |
| Zdroj: | Optometry and Vision Science. 98:109-112 |
| ISSN: | 1538-9235 1040-5488 |
| DOI: | 10.1097/opx.0000000000001641 |
| Popis: | Significance Alagille syndrome is rare genetic disease, which affects liver and heart function. Cases are frequently diagnosed late, and a complete ocular examination aids in the diagnosis. Although ophthalmic manifestations are usually benign, occasionally, sight-threatening complications occur. Purpose The case presented herein highlights a rare condition, which usually can be diagnosed by the ophthalmological findings. However, in this particular case report, the complication of angioid streaks and choroidal neovascularization is reported for the first time in Alagille syndrome. Case report Α 32-year-old woman diagnosed with Alagille syndrome presented with diminution of vision in the left eye. The cause was choroidal neovascularization related to angioid streaks. She was treated with intravitreal injections of ranibizumab but developed an extensive macular scar. A few years later, she developed the same complication in the right eye and was treated similarly. Conclusions Alagille syndrome has many ophthalmic manifestations, most of them benign with minimal threat to vision. Herein for the first time, we present a case of Alagille syndrome with angioid streak-related choroidal neovascularization, which resulted in severe vision loss. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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