Social opportunity rapidly regulates expression of CRF and CRF receptors in the brain during social ascent of a teleost fish, Astatotilapia burtoni

Autor: Lisa Becker, Russell D. Fernald, Russ E. Carpenter, Karen P. Maruska
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
Sexual Reproduction
Astatotilapia burtoni
Hydrocortisone
Corticotropin-Releasing Hormone
Physiology
Pituitary-Adrenal System
Gene Expression
lcsh:Medicine
Hierarchy
Social
Nervous System
Biochemistry
Mechanical Treatment of Specimens
Corticotropin-releasing hormone
Behavioral Neuroscience
0302 clinical medicine
Reproductive Physiology
Neural Pathways
Receptor
lcsh:Science
0303 health sciences
Multidisciplinary
Behavior
Animal
Neurochemistry
Cichlids
Neurotransmitters
Animal Models
Preoptic area
Electroporation
Specimen Disruption
Pituitary Gland
Anatomy
hormones
hormone substitutes
and hormone antagonists
Research Article
medicine.medical_specialty
Hypothalamo-Hypophyseal System
endocrine system
Neural Networks
Endocrine System
Biology
Research and Analysis Methods
Receptors
Corticotropin-Releasing Hormone
03 medical and health sciences
Fish physiology
Prosencephalon
Model Organisms
Cichlid
Internal medicine
medicine
Genetics
Animals
030304 developmental biology
lcsh:R
Reproductive System
Biology and Life Sciences
biology.organism_classification
Preoptic Area
Neuroanatomy
Endocrinology
Specimen Preparation and Treatment
Forebrain
lcsh:Q
Serotonin
Territoriality
Physiological Processes
030217 neurology & neurosurgery
Neuroscience
Zdroj: PLoS ONE, Vol 9, Iss 5, p e96632 (2014)
PLoS ONE
ISSN: 1932-6203
Popis: In social animals, hierarchical rank governs food availability, territorial rights and breeding access. Rank order can change rapidly and typically depends on dynamic aggressive interactions. Since the neuromodulator corticotrophin releasing factor (CRF) integrates internal and external cues to regulate the hypothalamic-pituitary adrenal (HPA) axis, we analyzed the CRF system during social encounters related to status. We used a particularly suitable animal model, African cichlid fish, Astatotilapia burtoni, whose social status regulates reproduction. When presented with an opportunity to rise in rank, subordinate A. burtoni males rapidly change coloration, behavior, and their physiology to support a new role as dominant, reproductively active fish. Although changes in gonadotropin-releasing hormone (GnRH1), the key reproductive molecular actor, have been analyzed during social ascent, little is known about the roles of CRF and the HPA axis during transitions. Experimentally enabling males to ascend in social rank, we measured changes in plasma cortisol and the CRF system in specific brain regions 15 minutes after onset of social ascent. Plasma cortisol levels in ascending fish were lower than subordinate conspecifics, but similar to levels in dominant animals. In the preoptic area (POA), where GnRH1 cells are located, and in the pituitary gland, CRF and CRF1 receptor mRNA levels are rapidly down regulated in ascending males compared to subordinates. In the Vc/Vl, a forebrain region where CRF cell bodies are located, mRNA coding for both CRFR1 and CRFR2 receptors is lower in ascending fish compared to stable subordinate conspecifics. The rapid time course of these changes (within minutes) suggests that the CRF system is involved in the physiological changes associated with shifts in social status. Since CRF typically has inhibitory effects on the neuroendocrine reproductive axis in vertebrates, this attenuation of CRF activity may allow rapid activation of the reproductive axis and facilitate the transition to dominance.
Databáze: OpenAIRE
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