Abietane Diterpenoids from Salvia pachyphylla and S. clevelandii with Cytotoxic Activity against Human Cancer Cell Lines
| Autor: | Leticia G. Leon, José Delgadillo, José M. Padrón, Rubén P Machín, L. S. Andrés, Iván Córdova Guerrero, J. G. Luis |
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| Rok vydání: | 2006 |
| Předmět: |
Stereochemistry
Pharmaceutical Science Salvia Carnosol Analytical Chemistry chemistry.chemical_compound Pachyphyllone Cell Line Tumor Drug Discovery Animals Humans Mexico Salvia clevelandii Abietane Pharmacology Plants Medicinal Molecular Structure biology Organic Chemistry Carnosic acid biology.organism_classification Antineoplastic Agents Phytogenic Complementary and alternative medicine chemistry Abietanes Molecular Medicine Drug Screening Assays Antitumor Diterpene Salvia pachyphylla |
| Zdroj: | Journal of Natural Products. 69:1803-1805 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np060279i |
| Popis: | A phytochemical study has been carried out on the aerial parts of Salvia pachyphylla and S. clevelandii. From S. pachyphylla, the known diterpenes carnosol (2), rosmanol, 20-deoxocarnosol (3), carnosic acid, isorosmanol (4), 7-methoxyrosmanol, 5,6-didehydro-O-methylsugiol (5), 8beta-hydroxy-9(11),13-abietadien-12-one (6), 11,12-dioxoabieta-8,13-diene, and 11,12-dihydroxy-20-norabieta-5(10),8,11,13-tetraen-1-one were isolated, together with the new diterpene pachyphyllone (1). From S. clevelandii, the known diterpenes rosmadial (7), 16-hydroxycarnosol (8), abieta-8,11,13-triene, and taxodone were obtained, together with carnosol (2), rosmanol, and carnosic acid. The structure of the new compound (1) was identified on the basis of spectroscopic data analysis. Several of these compounds (1-8) were evaluated against a small panel of human cancer cell lines. |
| Databáze: | OpenAIRE |
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