Restless legs syndrome and cardiovascular diseases: A case-control study
| Autor: | Yves Dauvilliers, Sofiene Chenini, Lily Guiraud, Isabelle Jaussent, Séverine Béziat, Marion Cholley-Roulleau |
|---|---|
| Přispěvatelé: | Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Pulmonology Physiology Apnea lcsh:Medicine Blood Pressure 030204 cardiovascular system & hematology Cardiovascular Medicine Vascular Medicine Body Mass Index 0302 clinical medicine Risk Factors Surveys and Questionnaires Insomnia 80 and over Medicine and Health Sciences Restless legs syndrome lcsh:Science Stroke 2. Zero hunger Aged 80 and over Multidisciplinary Depression Confounding Age Factors Sleep apnea Middle Aged 3. Good health Neurology Cardiovascular Diseases Hypertension Dopamine Agonists [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Female medicine.symptom Arrhythmia Research Article Primary Hypertension Adult medicine.medical_specialty Sleep Apnea Hypercholesterolemia Cardiology 03 medical and health sciences Sex Factors Sleep Apnea Syndromes [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Internal medicine Restless Legs Syndrome mental disorders Mental Health and Psychiatry medicine Humans cardiovascular diseases Aged business.industry Mood Disorders lcsh:R Case-control study Biology and Life Sciences medicine.disease Dyssomnias Heart failure Case-Control Studies lcsh:Q [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business Sleep Disorders Physiological Processes Sleep Body mass index 030217 neurology & neurosurgery |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2017, 12 (4), pp.e0176552. ⟨10.1371/journal.pone.0176552⟩ PLoS ONE, Vol 12, Iss 4, p e0176552 (2017) |
| ISSN: | 1932-6203 |
| Popis: | International audience; The association between restless legs syndrome (RLS), cardiovascular diseases (CVD) and hypertension is inconsistent. This case-control study examined i) the association between primary RLS, CVD and hypertension by taking into account many potential confounders and ii) the influence of RLS duration, severity and treatment, sleep and depressive symptoms on CVD and hypertension in primary RLS.METHODS: A standardized questionnaire to assess the RLS phenotype, history of CVD and hypertension, sleep and depressive symptoms, drug intake and demographic/clinical features was sent to the France-Ekbom Patients Association members. A CVD event was defined as a self-reported history of coronary heart disease, heart failure, arrhythmia or stroke. Hypertension was also self-assessed. Current treatment for hypertension and arrhythmia also defined underlying hypertension and arrhythmia. Controls without RLS and without consanguinity were chosen by the patients. RESULTS: 487 patients with primary RLS (median age 71 years; 67.4% women) and 354 controls (68 years, 47.7% women) were included. Most of the patients (91.7%) were treated for RLS, especially with dopaminergic agonists. The median age of RLS onset was 45 years. CVD and hypertension were associated with RLS in unadjusted association, but not after adjustment for age, sex and body mass index. Patients with RLS and with CVD and/or hypertension were significantly older, with hypercholesterolemia, sleep apnea and older age at RLS and at daily RLS onset compared with patients without CVD and/or hypertension. No significant difference was found for other RLS features, ferritin levels, daytime sleepiness, insomnia and depressive symptoms.CONCLUSION: Despite some limitations in the design of this study, we found that most of the treated patients for primary RLS had no association with CVD and hypertension after controlling for key potential confounders. Comorbid CVD or hypertension was associated with cardiovascular risk factors, but not with RLS features except for older age at onset. |
| Databáze: | OpenAIRE |
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