The Decoy Receptor 3 (DcR3, TNFRSF6B) suppresses Th17 immune responses and is abundant in human cerebrospinal fluid
| Autor: | Andreas Steinbrecher, André M. Mueller, Stephan Killian, Monique David, Xiomara Pedré |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
CD4-Positive T-Lymphocytes
Encephalomyelitis Autoimmune Experimental Fas Ligand Protein Recombinant Fusion Proteins T-Lymphocytes T cell Immunology Biology Interleukin-23 Fas ligand Immune tolerance Interferon-gamma Mice Immune system Immune Tolerance medicine Animals Humans Immunology and Allergy Interferon gamma fas Receptor Receptor Interleukin-6 Interleukin-17 Receptors Tumor Necrosis Factor Member 6b Mice Mutant Strains Cell biology Mice Inbred C57BL Disease Models Animal medicine.anatomical_structure Neurology Encephalitis Female Neurology (clinical) Decoy receptor 3 Interleukin 17 medicine.drug |
| Zdroj: | Journal of Neuroimmunology. 209:57-64 |
| ISSN: | 0165-5728 |
| Popis: | The Decoy Receptor 3 (DcR3) is known to compete with the signalling receptors of the Fas ligand (FasL), LIGHT and the TNF-like molecule 1A (TL1A). The primary aim of this study was to provide insights into the role of DcR3 in the modulation of myelin-specific encephalitogenic autoimmune T cell responses. Treatment of PLP-specific lymph node cells with DcR3.Fc protein resulted in a suppression of IFN-g and IL-17, in a reduced proportion of Th17 cells and in a decrease of encephalitogenicity. The Th17 response promoting cytokines IL-6 and IL-23 were suppressed by DcR3.Fc as well. DcR3.Fc-treatment of CD4+ T cells with a defective FasL did not influence the production of IL-17 indicating that DcR3 suppresses IL-17 production by disruption of Fas-FasL interactions. We identified high concentrations of DcR3 in the cerebrospinal fluid (CSF) of patients with various neurological disease states while almost no DcR3 was detected in corresponding serum samples. In conclusion, DcR3 modulates CNS-autoimmunity by interfering with Th17 responses via blockade of Fas-FasL interaction. The anti-inflammatory properties and high DcR3 concentrations in the CSF warrant further investigations in the expression pattern and the function of DcR3 within the CNS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect