Concentrations of rifampicin in pre-dose samples in patients with pulmonary tuberculosis
| Autor: | José Luiz Fernandes Vieira, Ana Carla Godinho Pinto, Breno Kristoffer Beleza Uchoa, Stefania de Medeiros Araujo Lucena, Carlos Augusto Abreu Albério |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Tuberculosis lcsh:QR1-502 Microbial Sensitivity Tests Gastroenterology lcsh:Microbiology lcsh:Infectious and parasitic diseases 03 medical and health sciences Minimum inhibitory concentration Young Adult Pulmonary tuberculosis Reference Values Internal medicine Blood plasma medicine Pre dose Humans In patient lcsh:RC109-216 Prospective Studies Antibiotics Antitubercular Tuberculosis Pulmonary Rifampicin Chromatography High Pressure Liquid Infectious disease 0303 health sciences Dose-Response Relationship Drug 030306 microbiology business.industry Sputum Reproducibility of Results Mycobacterium tuberculosis Middle Aged medicine.disease Infectious Diseases Treatment Outcome medicine.symptom Rifampin business medicine.drug |
| Zdroj: | Brazilian Journal of Infectious Diseases, Vol 23, Iss 2, Pp 130-133 (2019) Brazilian Journal of Infectious Diseases, Volume: 23, Issue: 2, Pages: 130-133, Published: 18 JUL 2019 |
| ISSN: | 1413-8670 |
| Popis: | Rifampicin is used in both phases of treatment for tuberculosis. In chronic use, the short half-life and the self-induction of metabolism can decrease the levels of the drug below the minimal inhibitory concentration. The aim of the study was to investigate whether plasma concentrations of rifampicin are sustained above 0.5 μg/mL in patients with tuberculosis using 600 mg/day. Rifampicin was measured in plasma by high-performance liquid chromatography and a sputum smear microscopy was performed in all days of the study. A total of 44 male patients completed the study. On days 31, 61 and 91, the mean plasma concentrations of rifampicin were 0.6 (0.5) μg/mL, 0.55 (0.5) μg/mL and 0.46 (0.4) μg/mL. There was a high variation of rifampicin levels leading to a high percentage of samples with concentrations below 0.5 μg/mL. There was no significant association between the frequency of samples with drug levels below 0.5 μg/mL with the conversion of the sputum microscopy. These data suggest that pre-doses samples offer limited information on the exposure of M. tuberculosis to rifampicin. Keywords: Infectious disease, Tuberculosis, Rifampicin |
| Databáze: | OpenAIRE |
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