Evaluación longitudinal mediante resonancia magnética del modelo de esquizofrenia de lesión neonatal en el hipocampo ventral
| Autor: | Carlos Alfonso Tovilla-Zárate, José Jaime Martínez-Magaña, Alma Delia Genis-Mendoza, Emilio Sacristan, Humberto Nicolini, Axayacatl Morales-Guadarrama, Carina Elizalde-Martínez, Brenda Cabrera-Mendoza, Isabel Beltrán-Villalobos |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.diagnostic_test
RD1-811 business.industry Esquizofrenia. Lesión neonatal del hipocampo ventral. Resonancia magnética Magnetic resonance imaging Hippocampal formation computer.software_genre Lesion Lateral ventricles Morphometric analysis Voxel Medicine Surgery medicine.symptom Nuclear medicine business computer |
| Zdroj: | Cirugía y Cirujanos, Vol 89, Iss 6 (2021) |
| Popis: | OBJECTIVE To evaluate the progression by means of nuclear magnetic resonance of the lesion in the schizophrenia model of lesion of the ventral hippocampal nucleus (LVNH). METHOD Magnetic resonance imaging (MRI) were performed in male Wistar rats, from 8 days postnatal to 139 days, in animals with LNHV and without lesion (sham). The MRI were carried out on a Variant 7 T equipment. The data were analyzed with the Amira software, for a voxel-based morphometric analysis. RESULTS We observed the presence of hypersignals with a significant enhancement in the structures analyzed in the group with LVNH, and greater volume in the lateral ventricles, presenting a larger size of the lesion on day PD96 and significantly reducing on day PD139. CONCLUSIONS We found a cell rearrangement during the progression of the lesion, which could be the effect of the activation of immune cells. |
| Databáze: | OpenAIRE |
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