A Sib-Pair Regression Model of Linkage Disequilibrium for Quantitative Traits
| Autor: | Lon R. Cardon |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Linkage disequilibrium
education.field_of_study Models Genetic Population Single-nucleotide polymorphism Regression analysis Biology Quantitative trait locus Polymorphism Single Nucleotide Linkage Disequilibrium Genetic architecture Nuclear Family Quantitative Trait Heritable Evolutionary biology Multivariate Analysis Genetics Humans education Association mapping Genetics (clinical) Genetic association |
| Zdroj: | Human Heredity. 50:350-358 |
| ISSN: | 1423-0062 0001-5652 |
| DOI: | 10.1159/000022940 |
| Popis: | A multiple-regression model is described for the detection of linkage disequilibrium in quantitative trait loci. The model is developed for application to large numbers of single nucleotide polymorphism (SNP) markers genotyped on small nuclear families. Parental data are not required by the method, although it provides a direct means to test quantitative trait locus-marker allele association and to determine whether any such association is attributable to linkage disequilibrium or population admixture. Analytical expectations for the regression coefficients are derived, allowing direct interpretation of the parameter estimates. Simulation studies indicate a substantial improvement in power over classical linkage studies of sibling pairs and show the effects of population admixture on the model outcomes. |
| Databáze: | OpenAIRE |
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