Differential Usage of an Autoantibody-associated VHGene, VH4-21, by Human B-cell Tumors
| Autor: | Terry J. Hamblin, M B Spellerberg, Freda K. Stevenson, Caroline J. Chapman |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Herpesvirus 4
Human Cancer Research Erythrocytes Lymphoma B-Cell Antibodies Neoplasm Chronic lymphocytic leukemia Gene Rearrangement B-Lymphocyte Heavy Chain Immunoglobulin Variable Region Follicular lymphoma Biology medicine.disease_cause Germline Immunoglobulin Idiotypes Antigen Leukemia B-Cell medicine Humans Gene Cryoglobulins Autoantibodies Cell Line Transformed Genetics B-Lymphocytes Mutation Genes Immunoglobulin Gene Expression Regulation Leukemic Autoantibody Antibodies Monoclonal Herpesviridae Infections Hematology medicine.disease Leukemia Lymphocytic Chronic B-Cell Gene Expression Regulation Neoplastic Tumor Virus Infections Oncology Agglutinins biology.protein Antibody |
| Zdroj: | Leukemia & Lymphoma. 16:379-385 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.3109/10428199509054423 |
| Popis: | Selection of immunoglobulin variable region genes for recombination in B cells takes place from among those VH and VL gene segments available in the unrearranged germ line repertoire. In the case of neoplastic B cells, there is apparent deviation in the use of V-genes from that expected on a random basis, both for VH and for VL. Also, the preferred V-genes, and their patterns of mutation, differ among the various categories of B-cell tumor possibly reflecting the distinct origins and clonal histories on the individual tumor cells. This review focuses on a single VH gene, VH4-21, which is a member of the VH4 family, and which appears selectively to encode immunoglobulins with autoantibody activity, particularly anti-red cell antibodies. The pattern of usage of this VH gene by B-cell tumors demonstrates clear asymmetry among different tumor types. Also, the mutations detected in this relatively non-polymorphic gene indicate that antigen, possibly autoantigen, may influence the behavior of the tumor cell. |
| Databáze: | OpenAIRE |
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