Differences in clinical characteristics and reported quality of life of men and women undergoing cardiac resynchronization therapy

Autor: Ahmad Hersi, David H. Birnie, Bart Gerritse, Michael R. Gold, Gerasimos Filippatos, Wilfried Mullens, Christophe Leclercq, Kengo Kusano, Bruce L. Wilkoff, Sandra Jacobs
Rok vydání: 2020
Předmět:
Male
medicine.medical_specialty
Cardiac resynchronization therapy outcome
medicine.medical_treatment
Population
Bundle-Branch Block
Cardiac resynchronization therapy
030204 cardiovascular system & hematology
law.invention
Cardiac Resynchronization Therapy
03 medical and health sciences
QRS complex
0302 clinical medicine
Quality of life
Randomized controlled trial
law
Internal medicine
medicine
Diseases of the circulatory (Cardiovascular) system
Humans
030212 general & internal medicine
PR interval
education
Heart Failure
education.field_of_study
Left bundle branch block
business.industry
LV pacing
medicine.disease
Kansas City Cardiomyopathy Questionnaire
Treatment Outcome
Gender differences in heart failure
RC666-701
Heart failure
Quality of Life
Female
AV conduction
Cardiology and Cardiovascular Medicine
business
Zdroj: ESC Heart Failure, Vol 7, Iss 5, Pp 2972-2982 (2020)
ISSN: 2055-5822
Popis: Aims Response to cardiac resynchronization therapy (CRT) is known to be associated with a number of clinical characteristics, including QRS duration and morphology, gender, height, and the aetiology of heart failure (HF). We assessed the relation of gender and baseline characteristics with QRS duration and Kansas City Cardiomyopathy Questionnaire. Methods and results AdaptResponse is a global randomized trial. The trial enrolled CRT‐indicated patients with New York Heart Association classes II–IV HF, left bundle branch block (QRS ≥ 140 ms in men, ≥130 ms in women), and baseline PR interval ≤200 ms. In total, 3620 patients were randomized, including 1569 women (43.3%) approaching the actual proportion of women in the HF population. Women were older and more often New York Heart Association class III or IV than men (55.6% vs. 48.7%), had less frequent ischaemic cardiomyopathy (21.2% vs. 39.5%), and had a 5.1 ms shorter QRS duration than men. Women were more often depressed (18.5% vs. 9.7%), had a significantly lower Kansas City Cardiomyopathy Questionnaire score, and had differences in medication prescriptions. Conclusions AdaptResponse is the largest randomized CRT trial and enrolled more women than any other landmark CRT trial. Women differed from men with regard to baseline characteristics and quality of life. Whether these differences translate into clinical outcome differences will be examined further in the AdaptResponse trial.
Databáze: OpenAIRE
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