Regulation of apoptosis by insulin-like growth factor (IGF)-I
Autor: | Ron Kooijman |
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Přispěvatelé: | Pharmacology, Neuroendocrine Immunology |
Jazyk: | angličtina |
Rok vydání: | 2006 |
Předmět: |
Receptor
IGF Type 1/antagonists & inhibitors Endocrinology Diabetes and Metabolism medicine.medical_treatment Immunology Biology Signal transduction Inhibitor of apoptosis General Biochemistry Genetics and Molecular Biology Receptor IGF Type 1 Insulin-like growth factor medicine Immunology and Allergy Animals Humans Insulin-Like Growth Factor I Autocrine signalling Protein kinase B Tissue homeostasis Medicine(all) Insulin-Like Growth Factor I/physiology apoptosis JAK-STAT signaling pathway Cell biology Apoptosis Cancer research |
Popis: | IGF-I is important for fetal and post-natal development, but it also controls tissue homeostasis throughout life via regulation of cell proliferation and apoptosis. This review summarizes our current understanding of how IGF-I receptor signaling interferes with the apoptotic machinery of the cell. IGF-I acts at different control points of apoptosis, including the Bcl-2 family proteins, inhibitors of caspases and signaling of death-inducing receptors. The main focal point of IGF-I is the regulation of Bcl-2 family proteins. Several signaling pathways converge to both the phosphorylation and transcriptional regulation of these proteins. This phenomenon may explain the efficacy of IGF-I as an inhibitor of apoptosis in many different cell types and in the presence of different apoptogenic stimuli. |
Databáze: | OpenAIRE |
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