Do Corticosteroid Injections for the Treatment of Pain Influence the Efficacy of mRNA COVID-19 Vaccines?
| Autor: | David C Miller, Clark Smith, Jaymin Patel, Adrian Popescu, Jennifer A. Punt, Milan Stojanovic, Zachary L McCormick, Ameet S. Nagpal, Haewon Lee, Yusef Sayeed |
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| Rok vydání: | 2021 |
| Předmět: |
Messenger ribonucleic acid
2019-20 coronavirus outbreak COVID-19 Vaccines Time Factors Coronavirus disease 2019 (COVID-19) medicine.drug_class Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Pain Inflammation Pharmacology 03 medical and health sciences 0302 clinical medicine Adrenal Cortex Hormones Humans Medicine 030212 general & internal medicine Intraarticular Corticosteroid 030304 developmental biology Vaccines Synthetic 0303 health sciences Messenger RNA business.industry COVID-19 General Medicine Anesthesiology and Pain Medicine Corticosteroid Patient Safety Neurology (clinical) medicine.symptom AcademicSubjects/MED00010 business |
| Zdroj: | Pain Medicine: The Official Journal of the American Academy of Pain Medicine |
| ISSN: | 1526-4637 1526-2375 |
| Popis: | Myth Corticosteroid injection for the treatment of pain and inflammation is known to decrease the efficacy of the messenger ribonucleic acid (mRNA) vaccines for coronavirus disease 2019 (COVID-19). Fact There is currently no direct evidence to suggest that a corticosteroid injection before or after the administration of an mRNA COVID-19 vaccine decreases the efficacy of the vaccine. However, based on the known timeline of hypothalamic-pituitary-adrenal (HPA) axis suppression following epidural and intraarticular corticosteroid injections, and the timeline of the reported peak efficacy of the Pfizer-BioNTech and Moderna vaccines, physicians should consider timing an elective corticosteroid injection such that it is administered no less than 2 weeks prior to a COVID-19 mRNA vaccine dose and no less than 1 week following a COVID-19 mRNA vaccine dose, whenever possible. |
| Databáze: | OpenAIRE |
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