The effects of Vilazodone, YL-0919 and Vortioxetine in hemiparkinsonian rats

Autor:	Samantha Smith, Jordan Sergio, Michael Coyle, Kayla Elder, Ashley Centner, Sophie Cohen, Michelle Terry, Natalie Lipari, John Glinski, Emily Wheelis, Carla Budrow, Christopher Bishop
Rok vydání:	2022
Předmět:	Serotonin Plasma Membrane Transport Proteins Pharmacology Dyskinesia Drug-Induced Serotonin Pyridones Dopamine Vilazodone Hydrochloride Neurodegenerative Diseases Corpus Striatum Rats Antiparkinson Agents Levodopa Rats Sprague-Dawley Disease Models Animal Piperidines Animals Humans Female Vortioxetine Oxidopamine
Zdroj:	Psychopharmacology. 239:2119-2132
ISSN:	1432-2072 0033-3158
Popis:	Parkinson's disease is a neurodegenerative disease often characterized by motor deficits and most commonly treated with dopamine replacement therapy. Despite its benefits, chronic use of L-DOPA results in abnormal involuntary movements known as L-DOPA-induced dyskinesia. Growing evidence shows that with burgeoning dopamine cell loss, neuroplasticity in the serotonin system leads to the development of L-DOPA-induced dyskinesia through the unregulated uptake, conversion, and release of L-DOPA-derived dopamine into the striatum. Previous studies have shown that coincident 5-HT
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b905b1bb659cb25b81a2ad40b909820a https://doi.org/10.1007/s00213-022-06078-9 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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