Toxic effects of bis(thiosemicarbazone) compounds and its palladium(II) complexes on herpes simplex virus growth
| Autor: | Ana I. Matesanz, Desislava Marinova, T. Varadinova, Pilar Souza, Petia Genova |
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| Rok vydání: | 2003 |
| Předmět: |
Thiosemicarbazones
Magnetic Resonance Spectroscopy Cell Survival viruses Herpesvirus 2 Human Blotting Western Acyclovir Herpesvirus 1 Human Biology Toxicology medicine.disease_cause Virus Replication Antiviral Agents Herpesviridae Virus Viral Proteins Dogs Viral entry Drug Resistance Viral medicine Organometallic Compounds Animals Aciclovir Cells Cultured Pharmacology Wild type Virology Kinetics Herpes simplex virus Capsid Viral replication Palladium medicine.drug |
| Zdroj: | Toxicology and applied pharmacology. 197(2) |
| ISSN: | 0041-008X |
| Popis: | Here, we present data on the activity of benzyl bis(thiosemicarbazone); 3,5-diacyl-1,2,4-triazole bis(4-methylthiosemicarbazone) and their Pd(II) complexes against the replication of wild type and of acyclovir (ACV)-resistant, herpes simplex virus type 1 (HSV 1) and type 2 (HSV 2) strains. The data were compared to those under the action of acyclovir. The testing of cytotoxic activity suggests that these compounds may be endowed with important antiviral properties. It is interesting to note that the Pd(II)-benzyl bis(thiosemicarbazone) complex, 2, exhibits a significant activity against acyclovir-resistant viruses R-100 (HSV 1) and PU (HSV 2) with an in vitro selectivity index (SI) of 8.0 vs. 0.01 for acyclovir. This complex also negatively influenced the expression of key structural HSV 1 proteins (VP23, gH and gG/gD), thus suppressing simultaneously virus entry, transactivation of virus genome, capsid assembly, and cell-to-cell spread of infectious HSV progeny. |
| Databáze: | OpenAIRE |
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