Facile Synthesis of 1,6-Bis(2-furyl)-2,5-bis(2-hydroxy-3-formyl-5-methylbenzyl)-2,5-diazahexane: a New Dinucleating Ligand
| Autor: | Guo-Xi Wang, Liu-Fang Wang, Chang-Rang Liu, Gang-Chun Sun, Zhan-Hang He, Xiao-Dong Yuan, Zhi-Juan Yang, Zhong-Jun Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Pharmaceutical Science
chemistry.chemical_element Manganese dioxide Manganese Medicinal chemistry Article Analytical Chemistry Turn (biochemistry) lcsh:QD241-441 chemistry.chemical_compound Synthesis Dinucleating ligand lcsh:Organic chemistry Drug Discovery Organic chemistry Hydroxymethyl Physical and Theoretical Chemistry Ethanol Ligand Organic Chemistry Partial oxididation 2 5-Diazahexane derivative chemistry Chemistry (miscellaneous) Molecular Medicine 5-Diazahexane derivative |
| Zdroj: | Molecules Volume 6 Issue 12 Pages 1001-1005 Molecules, Vol 6, Iss 12, Pp 1001-1005 (2001) Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/61201001 |
| Popis: | A convenient three-step preparation of the dinucleating ligand, 1,6-bis(2-furyl)-2,5-bis(2-hydroxy-3-formyl-5-methylbenzyl)-2,5-diazahexane (3) starting from 2,6-bis(hydroxymethyl)-4-methylphenol (4) is reported. Compound 4 was partially oxidized with preactivated manganese dioxide to form compound 5, which was converted to 2-hydroxy-3-chloromethyl-5-ethylbenzaldehyde (6) with conc.HCl/EtOH. Compound 6 in turn reacted with N,N’-bis (2-furyl)-1,2-diaminoethane (7) in the presence of K2CO3 in ethanol to give the title compound 3. No protecting groups were required in the whole process and the conditions were mild. |
| Databáze: | OpenAIRE |
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