Association of plasma YKL-40 with brain amyloid-β levels, memory performance, and sex in subjective memory complainers

Autor: Andrea Vergallo, Simone Lista, Pablo Lemercier, Patrizia A. Chiesa, Henrik Zetterberg, Kaj Blennow, Marie-Claude Potier, Marie-Odile Habert, Filippo Baldacci, Enrica Cavedo, Filippo Caraci, Bruno Dubois, Harald Hampel, Hovagim Bakardjian, Habib Benali, Hugo Bertin, Joel Bonheur, Laurie Boukadida, Nadia Boukerrou, Patrizia Chiesa, Olivier Colliot, Marion Dubois, Stéphane Epelbaum, Geoffroy Gagliardi, Remy Genthon, Marion Houot, Aurélie Kas, Foudil Lamari, Marcel Levy, Christiane Metzinger, Fanny Mochel, Francis Nyasse, Catherine Poisson, Marie Revillon, Antonio Santos, Katia Santos Andrade, Marine Sole, Mohmed Surtee, Michel Thiebaut de Schotten, Nadjia Younsi, Mohammad Afshar, Lisi Flores Aguilar, Leyla Akman-Anderson, Joaquín Arenas, Jesús Ávila, Claudio Babiloni, Richard Batrla, Norbert Benda, Keith L. Black, Arun L.W. Bokde, Ubaldo Bonuccelli, Karl Broich, Francesco Cacciola, Giuseppe Caruso, Juan Castrillo†, Roberto Ceravolo, Massimo Corbo, Jean-Christophe Corvol, Augusto Claudio Cuello, Jeffrey L. Cummings, Herman Depypere, Andrea Duggento, Enzo Emanuele, Valentina Escott-Price, Howard Federoff, Maria Teresa Ferretti, Massimo Fiandaca, Richard A. Frank, Francesco Garaci, Hugo Geerts, Ezio Giacobini, Filippo S. Giorgi, Edward J. Goetzl, Manuela Graziani, Marion Haberkamp, Britta Hänisch, Karl Herholz, Felix Hernandez, Bruno P. Imbimbo, Dimitrios Kapogiannis, Eric Karran, Steven J. Kiddle, Seung H. Kim, Yosef Koronyo, Maya Koronyo-Hamaoui, Todd Langevin, Stéphane Lehéricy, Francisco Llavero, Jean Lorenceau, Alejandro Lucía, Dalila Mango, Mark Mapstone, Christian Neri, Robert Nisticò, Sid E. O’bryant, Giovanni Palermo, George Perry, Craig Ritchie, Simone Rossi, Amira Saidi, Emiliano Santarnecchi, Lon S. Schneider, Olaf Sporns, Nicola Toschi, Pedro L. Valenzuela, Bruno Vellas, Steven R. Verdooner, Nicolas Villain, Kelly Virecoulon Giudici, Mark Watling, Lindsay A. Welikovitch, Janet Woodcock, Erfan Younesi, José L. Zugaza
Přispěvatelé: Alzheimer Precision Medicine [CHU Pitié-Salpétriêre] (GRC 21 AMP), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
musculoskeletal diseases
0301 basic medicine
Apolipoprotein E
Male
Risk
Aging
medicine.medical_specialty
Amyloid
YKL-40
[SDV]Life Sciences [q-bio]
Disease
03 medical and health sciences
Alzheimer's disease
amyloid
neuroinflammation
Sex
0302 clinical medicine
Neuroinflammation
Alzheimer Disease
Memory
Internal medicine
medicine
Premovement neuronal activity
Humans
Effects of sleep deprivation on cognitive performance
Chitinase-3-Like Protein 1
Longitudinal Studies
Inflammation
Amyloid beta-Peptides
business.industry
General Neuroscience
Neurodegeneration
Settore FIS/07
Brain
medicine.disease
030104 developmental biology
Endocrinology
Biomarker (medicine)
Female
Neurology (clinical)
Geriatrics and Gerontology
business
Alzheimer’s disease
030217 neurology & neurosurgery
Biomarkers
Developmental Biology
Zdroj: Neurobiology of Aging
Neurobiology of Aging, Elsevier, 2020, 96, pp.22-32. ⟨10.1016/j.neurobiolaging.2020.07.009⟩
ISSN: 0197-4580
Popis: Neuroinflammation, a key early pathomechanistic alteration of Alzheimer’s disease, may represent either a detrimental or a compensatory mechanism or both (according to the disease stage). YKL-40, a glycoprotein highly expressed in differentiated glial cells, is a candidate biomarker for in vivo tracking neuroinflammation in humans. We performed a longitudinal study in a monocentric cohort of cognitively healthy individuals at risk for Alzheimer’s disease exploring whether age, sex, and the apolipoprotein E e4 allele affect plasma YKL-40 concentrations. We investigated whether YKL-40 is associated with brain amyloid-β (Aβ) deposition, neuronal activity, and neurodegeneration as assessed via neuroimaging biomarkers. Finally, we investigated whether YKL-40 may predict cognitive performance. We found an age-associated increase of YKL-40 and observed that men display higher concentrations than women, indicating a potential sexual dimorphism. Moreover, YKL-40 was positively associated with memory performance and negatively associated with brain Aβ deposition (but not with metabolic signal). Consistent with translational studies, our results suggest a potentially protective effect of glia on incipient brain Aβ accumulation and neuronal homeostasis.
Databáze: OpenAIRE
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