Evaluation of a new controlled-drug delivery concept based on the use of thermoresponsive polymers
| Autor: | Karim Amighi, Frédéric Eeckman, André Jules Moes |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
chemistry.chemical_classification
Hot Temperature Materials science Polymers Acrylic Resins Pharmaceutical Science Polymer Lower critical solution temperature Dosage form Molecular Weight Solubility Theophylline chemistry Chemical engineering Delayed-Action Preparations Drug delivery Polymer chemistry Indicators and Reagents Thermoresponsive polymers in chromatography Particle Size Drug carrier Dissolution Tablets |
| Zdroj: | International Journal of Pharmaceutics. 241:113-125 |
| ISSN: | 0378-5173 |
| DOI: | 10.1016/s0378-5173(02)00198-9 |
| Popis: | The purpose of this work is to develop a new delivery concept making a thermosensitive polymer based on poly(N-isopropylacrylamide) (PNIPAAm) useful as a time-controlled drug release device, without any temperature changes of the dissolution medium. It was previously found that some salts induce a decrease of the polymer lower critical solution temperature (LCST). Use is here made of that property to show that salt concentration variations can be used as a substitute for temperature changes to make the polymer coating of compression-coated tablets soluble or insoluble, consequently creating a possible new concept of drug delivery control from delivery systems containing thermoresponsive polymers. The obtained results show the influence of the type and amount of salts incorporated into compression-coated tablets on the release lag time of a model drug. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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