Sphingolipid metabolic flow controls phosphoinositide turnover at the trans ‐Golgi network
| Autor: | Maarit Hölttä-Vuori, Josse van Galen, Angelika Hausser, Serena Capasso, Giovanni D'Angelo, Gabriele Turacchio, Vivek Malhotra, Domenico Russo, Lucia Sticco, Seetharaman Parashuraman, Marinella Pirozzi, Isabelle Riezman, Howard Riezman, Elina Ikonen, Riccardo Rizzo, Nina A. Dathan, Chiara Luberto, Alberto Luini, Felix Campelo |
|---|---|
| Předmět: |
0301 basic medicine
PtdIns(4)P Ceramide Membrane lipids membrane contact sites Biology Phosphatidylinositols Models Biological General Biochemistry Genetics and Molecular Biology lipid territories Dephosphorylation 03 medical and health sciences symbols.namesake chemistry.chemical_compound ceramide lipid-transfer protein Lipid‐transfer protein Homeostasis Humans Molecular Biology Sphingolipids Membrane contact sites General Immunology and Microbiology General Neuroscience Articles Golgi apparatus Lipid territories Sphingolipid Hedgehog signaling pathway Cell biology carbohydrates (lipids) 030104 developmental biology Biochemistry chemistry ddc:540 symbols lipids (amino acids peptides and proteins) Sphingomyelin lipid‐transfer protein Plant lipid transfer proteins HeLa Cells trans-Golgi Network |
| Zdroj: | EMBO Journal, Vol. 36, No 12 (2017) pp. 1736-1754 EMBO journal (Online) Volume 36, (2017). doi:10.15252/embj.201696048 info:cnr-pdr/source/autori:Serena Capasso, Lucia Sticco, Riccardo Rizzo, Marinella Pirozzi, Domenico Russo, Nina A Dathan, Felix Campelo, Josse van Galen, Maarit Hölttä-Vuori, Gabriele Turacchio, Angelika Hausser, Vivek Malhotra, Isabelle Riezman, Howard Riezman, Elina Ikonen, Chiara Luberto, Seetharaman Parashuraman, Alberto Luini, Giovanni D'Angelo/titolo:Sphingolipid metabolic flow controls phosphoinositide turnover at the trans-Golgi network/doi:10.15252%2Fembj.201696048/rivista:EMBO journal (Online)/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:Volume 36 |
| ISSN: | 0261-4189 |
| DOI: | 10.15252/embj.201696048 |
| Popis: | Sphingolipids are membrane lipids globally required for eukaryotic life. The sphingolipid content varies among endomembranes with pre‐ and post‐Golgi compartments being poor and rich in sphingolipids, respectively. Due to this different sphingolipid content, pre‐ and post‐Golgi membranes serve different cellular functions. The basis for maintaining distinct subcellular sphingolipid levels in the presence of membrane trafficking and metabolic fluxes is only partially understood. Here, we describe a homeostatic regulatory circuit that controls sphingolipid levels at the trans‐Golgi network (TGN). Specifically, we show that sphingomyelin production at the TGN triggers a signalling pathway leading to PtdIns(4)P dephosphorylation. Since PtdIns(4)P is required for cholesterol and sphingolipid transport to the trans‐Golgi network, PtdIns(4)P consumption interrupts this transport in response to excessive sphingomyelin production. Based on this evidence, we envisage a model where this homeostatic circuit maintains a constant lipid composition in the trans‐Golgi network and post‐Golgi compartments, thus counteracting fluctuations in the sphingolipid biosynthetic flow. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|