Impact of HCV cure with drug-acting antivirals in the use of concomitant medication and lipid profile: follow-up data 2 years after the sustained virological response
| Autor: | Santiago Grau, Marc Batlle, Marta de Antonio-Cuscó, Anna Viu, Xavier Bessa, E González-Colominas, José A. Carrión, Xavier Duran, Inés Monge-Escartín |
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| Rok vydání: | 2020 |
| Předmět: |
Drug
medicine.medical_specialty Cirrhosis Sustained Virologic Response media_common.quotation_subject Hepacivirus Antiviral Agents Virological response 03 medical and health sciences 0302 clinical medicine Older patients Internal medicine medicine Humans Prospective Studies Prospective cohort study Aged media_common Hepatology medicine.diagnostic_test business.industry Gastroenterology Hepatitis C Chronic medicine.disease Lipids Treatment Outcome medicine.anatomical_structure Pharmaceutical Preparations 030220 oncology & carcinogenesis Concomitant Vascular resistance Drug Therapy Combination 030211 gastroenterology & hepatology Lipid profile business Follow-Up Studies |
| Zdroj: | European Journal of Gastroenterology & Hepatology. 32:214-222 |
| ISSN: | 0954-691X |
| Popis: | BACKGROUND AND AIM Patients with chronic hepatitis C (CHC) frequently associated comorbidities and concomitant medication. Sustained virological response (SVR12) has been related to an increase in cholesterol serum levels and in peripheral vascular resistance. Our aim was to evaluate the impact of SVR12 on the use of concomitant medication and serum lipid profile. METHODS Prospective study including patients treated with direct-acting antivirals who had achieved the SVR12. Clinical data and concomitant drugs were analysed at baseline and at least 1 year after SVR12. Differences from baseline to follow-up in the concomitant medication were evaluated by Stuart-Maxwell test and lipid profile by Wilcoxon signed-rank test. Patients were categorized according to the increase/decrease in the number of drugs included in each class (Anatomical Therapeutic Chemical classification system). RESULTS Two hundred twenty-six patients with SVR12 were included, 73.5% were receiving concomitant drugs (49.6% with antihypertensive effect, 30.5% antacids, 16.4% anti-diabetic drugs, and 7.1% lipid-lowering agents). One year after SVR12, total cholesterol serum levels increased from 161 to 179 mg/dl (P < 0.001) and, after a median time of 25.7 months, the use of lipid-lowering drugs increased from 7.8 to 11.5% (P = 0.009). In addition, we observed a trend to use more antihypertensive drugs in older patients (P = 0.06), especially in those with cirrhosis. Anxiolytics decreased after SVR12 from 13.7 to 10.6% (P = 0.035). CONCLUSION CHC cure is associated with a significant increase in cholesterol serum levels and the use of lipid-lowering agents, as well as the use of drugs with antihypertensive effect in older patients. |
| Databáze: | OpenAIRE |
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