Differential Susceptibilities of Aedes aegypti and Aedes albopictus from the Americas to Zika Virus

Autor: Daniella Goindin, Marie Vazeille, Anubis Vega-Rúa, Anna-Bella Failloux, Romain Girod, André Yébakima, Myrielle Dupont-Rouzeyrol, Thaís Chouin-Carneiro, Ricardo Lourenço-de-Oliveira
Přispěvatelé: Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), Arbovirus et Insectes Vecteurs - Arboviruses and Insect Vectors, Institut Pasteur [Paris] (IP), Centre de Démoustication, Conseil Général de Martinique, Institut Pasteur de la Guyane, Institut Pasteur de la Guadeloupe, Institut Pasteur de Nouvelle-Calédonie, This study was funded by the Institut Pasteur, the French Government's Investissement d'Avenir program, Laboratoire d'Excellence 'Integrative Biology of Emerging Infectious Diseases' (grant n°ANR-10-LABX-62-IBEID). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), Fundação Oswaldo Cruz (FIOCRUZ), Institut Pasteur [Paris]
Rok vydání: 2016
Předmět:
0301 basic medicine
Viral Diseases
Epidemiology
Physiology
Disease Vectors
Mosquitoes
Geographical locations
Zika virus
0302 clinical medicine
Aedes
Genotype
Medicine and Health Sciences
MESH: Animals
Guadeloupe
education.field_of_study
lcsh:Public aspects of medicine
Temperature
MESH: Aedes
MESH: Temperature
Body Fluids
3. Good health
Insects
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
Infectious Diseases
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
MESH: Animal Structures
Anatomy
Martinique
Brazil
Research Article
lcsh:Arctic medicine. Tropical medicine
Aedes albopictus
Arthropoda
lcsh:RC955-962
030231 tropical medicine
Population
MESH: Zika Virus
MESH: Insect Vectors
Aedes aegypti
Biology
03 medical and health sciences
MESH: Humidity
parasitic diseases
MESH: Americas
Animals
MESH: Saliva
Saliva
education
Caribbean
fungi
Organisms
Public Health
Environmental and Occupational Health
Biology and Life Sciences
Chikungunya Infection
Animal Structures
Outbreak
lcsh:RA1-1270
Humidity
Zika Virus
South America
biology.organism_classification
Invertebrates
Virology
United States
Insect Vectors
030104 developmental biology
Vector (epidemiology)
North America
People and places
Americas
Zdroj: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 10, Iss 3, p e0004543 (2016)
PLoS Neglected Tropical Diseases, 2016, 10 (3), pp.e0004543. ⟨10.1371/journal.pntd.0004543⟩
PLoS Neglected Tropical Diseases, Public Library of Science, 2016, 10 (3), pp.e0004543. ⟨10.1371/journal.pntd.0004543⟩
ISSN: 1935-2735
1935-2727
DOI: 10.1371/journal.pntd.0004543
Popis: Background Since the major outbreak in 2007 in the Yap Island, Zika virus (ZIKV) causing dengue-like syndromes has affected multiple islands of the South Pacific region. In May 2015, the virus was detected in Brazil and then spread through South and Central America. In December 2015, ZIKV was detected in French Guiana and Martinique. The aim of the study was to evaluate the vector competence of the mosquito spp. Aedes aegypti and Aedes albopictus from the Caribbean (Martinique, Guadeloupe), North America (southern United States), South America (Brazil, French Guiana) for the currently circulating Asian genotype of ZIKV isolated from a patient in April 2014 in New Caledonia. Methodology/Principal Findings Mosquitoes were orally exposed to an Asian genotype of ZIKV (NC-2014-5132). Upon exposure, engorged mosquitoes were maintained at 28°±1°C, a 16h:8h light:dark cycle and 80% humidity. 25–30 mosquitoes were processed at 4, 7 and 14 days post-infection (dpi). Mosquito bodies (thorax and abdomen), heads and saliva were analyzed to measure infection, dissemination and transmission, respectively. High infection but lower disseminated infection and transmission rates were observed for both Ae. aegypti and Ae. albopictus. Ae. aegypti populations from Guadeloupe and French Guiana exhibited a higher dissemination of ZIKV than the other Ae. aegypti populations examined. Transmission of ZIKV was observed in both mosquito species at 14 dpi but at a low level. Conclusions/Significance This study suggests that although susceptible to infection, Ae. aegypti and Ae. albopictus were unexpectedly low competent vectors for ZIKV. This may suggest that other factors such as the large naïve population for ZIKV and the high densities of human-biting mosquitoes contribute to the rapid spread of ZIKV during the current outbreak.
Author Summary Zika virus (ZIKV) is an emerging mosquito-borne arbovirus causing dengue-like symptoms. This virus was commonly detected in Africa and Asia. Since its emergence in Yap Island in Micronesia in 2007, ZIKV reemerged in the South Pacific region in 2013 and ultimately reached the American continent in 2015. The human biting mosquito Aedes aegypti and the less anthropophilic Aedes albopictus have been incriminated as vectors of ZIKV. Our study showed that American populations of Ae. aegypti and Ae. albopictus were able to become infected and disseminate ZIKV within the mosquito general cavity at early days (4, 7) post-infection (dpi). Nevertheless, transmission was unexpectedly low and only detected at 14 dpi. Our findings will help in designing more adapted vector control strategies and limiting the impact of a new emerging threat on human health in the Americas as did the chikungunya in 2014.
Databáze: OpenAIRE
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