Overexpression of ANXA1 in Penile Carcinomas Positive for High-Risk HPVs
| Autor: | Mânlio Tasso de Oliveira Mota, Marilia Freitas Calmon, Erica Babeto, Luisa L. Villa, Paula Rahal, José Germano Ferraz de Arruda, Jorge Alberto Thomé, Rodrigo Vellasco Duarte Silvestre, Jane Lopes Bonilha, Sonia Maria Oliani, Gustavo Hernandez Américo Medeiros, Carlos Fabian Mendiburu, Natalia Maria Candido, Bruno Miziara Rosa, Ana Paula Girol, Fernando Augusto Soares, José Vassallo, Gustavo Cardoso Guimarães |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Institute of Anatomical Pathology and Cytopathology, College of Medicine of Rio Preto, University Hospital João de Berros Barreto, Hospital A. C. Camargo,São Paulo, Universidade de São Paulo (USP) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
squamous cell carcinoma
tumor classification Male Skin Neoplasms protein p16 KIAA1033 gene Gene Expression lcsh:Medicine high risk patient Polymerase Chain Reaction Risk Factors Penile Carcinoma Papillomaviridae lcsh:Science Skin Tumors papillomavirus infection Annexin A1 Aged 80 and over clinical article Multidisciplinary biology Squamous Cell Carcinomas virus diseases Nucleic Acid Hybridization ANXA1 gene Middle Aged Immunohistochemistry female genital diseases and pregnancy complications Gene Expression Regulation Neoplastic medicine.anatomical_structure Oncology penile squamous cell carcinoma Medicine geographic locations Research Article virus DNA Adult Human Papillomavirus Infection Human papillomavirus Genotype Urology gene overexpression Penile Neoplasm Malignant Skin Neoplasms PBEF1 gene Dermatology lipocortin 1 RPL6 gene Microbiology Wart virus Virology p16 gene Carcinoma medicine Genetics Penile cancer Humans controlled study Squamous Cell Carcinoma human gene Biology protein expression Penile Neoplasms Aged nonhuman Genitourinary Infections Gene Expression Profiling lcsh:R Papillomavirus Infections Cancer Cancers and Neoplasms Reproducibility of Results biology.organism_classification medicine.disease human tissue Viruses and Cancer penis carcinoma Cancer research lcsh:Q Penis |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP PLoS ONE, Vol 8, Iss 1, p e53260 (2013) PLoS ONE |
| ISSN: | 8487-2284 |
| Popis: | Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:28:11Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:32:14Z : No. of bitstreams: 1 2-s2.0-84872284943.pdf: 339604 bytes, checksum: 492cc1c4dc088810dce90bfeef2cd1a7 (MD5) Made available in DSpace on 2014-05-27T11:28:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-01-18 The incidence of penile cancer varies between populations but is rare in developed nations. Penile cancer is associated with a number of established risk factors and associated diseases including phimosis with chronic inflammation, human papillomavirus (HPV) infection, poor hygiene and smoking. The objective of this study was to identify genes related to this type of cancer. The detection of HPV was analyzed in 47 penile squamous cell carcinoma samples. HPV DNA was detected in 48.9% of penile squamous cell carcinoma cases. High-risk HPV were present in 42.5% of cases and low-risk HPV were detected in 10.6% of penile squamous cell carcinomas. The RaSH approach identified differential expression of Annexin A1 (ANXA1), p16, RPL6, PBEF1 and KIAA1033 in high-risk HPV positive penile carcinoma; ANXA1 and p16 were overexpressed in penile squamous cells positive for high-risk HPVs compared to normal penile samples by qPCR. ANXA1 and p16 proteins were significantly more expressed in the cells from high-risk HPV-positive penile carcinoma as compared to HPV-negative tumors (p |
| Databáze: | OpenAIRE |
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