Corticosterone in drinking water: altered kinetics of a single oral dose of corticosterone and concentrations of plasma sodium, albumin, globulin, and total protein
| Autor: | Marion Ehrich, Kurt L. Zimmerman, Thitiya Pung, Bradley G. Klein |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
0301 basic medicine
Chronic exposure medicine.medical_specialty Hypothalamo-Hypophyseal System Plasma sodium Health Toxicology and Mutagenesis Kinetics Pituitary-Adrenal System 010501 environmental sciences Toxicology 01 natural sciences Single oral dose 03 medical and health sciences chemistry.chemical_compound Norepinephrine Catecholamines Corticosterone Stress Physiological Water Supply Internal medicine medicine Animals Rats Long-Evans Serum Albumin 0105 earth and related environmental sciences Total protein 030102 biochemistry & molecular biology Ethanol Chemistry Sodium Public Health Environmental and Occupational Health Rats Albumin/Globulin Endocrinology Blood chemistry Acetylcholinesterase Serum Globulins Carboxylic Ester Hydrolases Blood Chemical Analysis Water Pollutants Chemical |
| Zdroj: | Toxicology and industrial health. 19(7-10) |
| ISSN: | 0748-2337 |
| Popis: | Effects of chronic exposure to corticosterone in drinking water on corticosterone kinetics, blood chemistry, and concentrations of catecholamines in parts of brain were studied in Long-Evans rats. Rats were randomly grouped into 3-2 treatments (n-4), with three treatments of drinking water (tap water, or 2.5% ethanol, or 400 mg/mL of corticosterone in 2.5% ethanol) for 28 days and two treatments of gavage with a single dose of either corn oil or corticosterone 20 mg/kg on day 28. Blood samples were collected at 0, 15, 30, 60, 120, 240, 480, and 720 min after dosing to determine plasma corticosterone concentrations. Blood samples were collected for clinical pathology on day 42. Hippocampus, cerebral cortex, caudate-putamen, and pons were examined to determine concentrations of catecholamines and activities of esterases. Concentrations of plasma corticosterone before gavage of the corticosterone-drinking rats (47.619 ± 1.13 ng/mL) were lower than the water (418.479 ± 1.13 ng/mL) or the ethanol rats (383.719 ± 1.13 ng/mL, P |
| Databáze: | OpenAIRE |
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