Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma

Autor:	Barbara Ensoli, Phillip D. Markham, Hsiao-Kuey Chang, Aurelio Cafaro, Sandra Colombini, Valeria Fiorelli, Robert C. Gallo, John N. Brady, Mark Raffeld, R Gendelman
Rok vydání:	1994
Předmět:	Basic fibroblast growth factor Molecular Sequence Data Palatine Tonsil Mice Nude Biology Virus Cell Line Pathogenesis Extracellular matrix chemistry.chemical_compound Mice medicine Extracellular Cell Adhesion Animals Humans Collagenases Receptor Kaposi's sarcoma Sarcoma Kaposi Skin Acquired Immunodeficiency Syndrome Extracellular Matrix Proteins Mice Inbred BALB C Multidisciplinary Base Sequence Molecular Mimicry virus diseases medicine.disease Virology Fibronectins Enzyme Activation chemistry Matrix Metalloproteinase 9 Gene Products tat Collagenase Cancer research HIV-1 Fibroblast Growth Factor 2 tat Gene Products Human Immunodeficiency Virus medicine.drug
Zdroj:	Nature. 371(6499)
ISSN:	0028-0836
Popis:	Basic fibroblast growth factor (bFGF) and human immunodeficiency virus type 1 (HIV-1) Tat protein synergize in inducing angiogenic Kaposi's sarcoma-like lesions in mice. Synergy is due to Tat, which enhances endothelial cell growth and type-IV collagenase expression in response to bFGF mimicking extracellular matrix proteins. The bFGF, extracellular Tat and Tat receptors are present in HIV-1-associated KS, which may explain the higher frequency and aggressiveness of this form compared to classical Kaposi's sarcoma where only bFGF is present.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f44127d23ed159657d91aaf163ad04 https://pubmed.ncbi.nlm.nih.gov/7935812 Zobrazit plný text záznamu