Vitamin D and COVID‐19: A review on the role of vitamin D in preventing and reducing the severity of COVID‐19 infection
| Autor: | Allison C Lindquist, Audrey E L Gerzema, Mobeen Abdrabbo, Hunter W Sillman, Sanchita Hati, Kelsey A Cicigoi, Michael A Smith, Caterra M Leavens, Ava C Gehrke, Nathaniel J Severson, Emily C Vanderpas, Christine N Le, Brandon A Sherman, Levi M Svaren, Stephen J Coffey, Abby Hansen, Alyssa C Huelsbeck, Ben LaBerge, Marissa J Snortheim, Alec J Wozney, Cole M Birch, Rickaela K Ludwig, Hannah Dvorak, Michael Brandt, Miles J Wackett, Macey A Smith, Connor C Dolan, Sudeep Bhattacharyya, Ethan J Henseler, Jacob H Reynolds |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
cholecalciferol
Reviews vitamin D Disease Review medicine.disease_cause Biochemistry Severity of Illness Index vitamin D deficiency SARS‐CoV‐2 chemistry.chemical_compound Viral entry COVID‐19 Vitamin D and neurology Medicine Humans Receptor Molecular Biology Coronavirus business.industry SARS-CoV-2 COVID-19 Virus Internalization medicine.disease Reactive Nitrogen Species Oxidative Stress chemistry Immunology Angiotensin-Converting Enzyme 2 business Cholecalciferol Reactive Oxygen Species Oxidative stress |
| Zdroj: | Protein Science : A Publication of the Protein Society |
| ISSN: | 1469-896X 0961-8368 |
| Popis: | Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) is a pathogenic coronavirus causing COVID‐19 infection. The interaction between the SARS‐CoV‐2 spike protein and the human receptor angiotensin‐converting enzyme 2, both of which contain several cysteine residues, is impacted by the disulfide‐thiol balance in the host cell. The host cell redox status is affected by oxidative stress due to the imbalance between the reactive oxygen/nitrogen species and antioxidants. Recent studies have shown that Vitamin D supplementation could reduce oxidative stress. It has also been proposed that vitamin D at physiological concentration has preventive effects on many viral infections, including COVID‐19. However, the molecular‐level picture of the interplay of vitamin D deficiency, oxidative stress, and the severity of COVID‐19 has remained unclear. Herein, we present a thorough review focusing on the possible molecular mechanism by which vitamin D could alter host cell redox status and block viral entry, thereby preventing COVID‐19 infection or reducing the severity of the disease. |
| Databáze: | OpenAIRE |
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