Inflammatory markers are altered in severe mental disorders independent of comorbid cardiometabolic disease risk factors
| Autor: | Thor Ueland, Ann Færden, Erlend Strand Gardsjord, Ingrid Dieset, Ingrid Melle, Eva Zsuzsanna Hoseth, Monica Aas, Ragni Helene Mørch, Ingrid Agartz, Srdjan Djurovic, Pål Aukrust, Trude Seselie Jahr Iversen, Inge Joa, Elina J Reponen, Gunnar Morken, Ole A. Andreassen, Sigrun Hope |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Adolescent Blood lipids Comorbidity Disease Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Bipolar disorder Applied Psychology ALCAM Aged Inflammation Mood Disorders Norway business.industry Confounding Middle Aged medicine.disease 030227 psychiatry Psychiatry and Mental health Cardiovascular Diseases Schizophrenia Cytokines Female business Body mass index 030217 neurology & neurosurgery |
| Zdroj: | Psychological Medicine. 49:1749-1757 |
| ISSN: | 1469-8978 0033-2917 |
| DOI: | 10.1017/s0033291718004142 |
| Popis: | BackgroundInflammation and immune activation have been implicated in the pathogenesis of severe mental disorders and cardiovascular disease (CVD). Despite high level of comorbidity, many studies of the immune system in severe mental disorders have not systematically taken cardiometabolic risk factors into account.MethodsWe investigated if inflammatory markers were increased in schizophrenia (SCZ) and affective (AFF) disorders independently of comorbid CVD risk factors. Cardiometabolic risk factors (blood lipids, body mass index and glucose) and CVD-related inflammatory markers CXCL16, soluble interleukin-2 receptor (sIL-2R), soluble CD14 (sCD14), macrophage inhibitory factor and activated leukocyte cell adhesion molecule (ALCAM) were measured inn= 992 patients (SCZ, AFF), andn= 647 healthy controls. We analyzed the inflammatory markers before and after controlling for comorbid cardiometabolic risk factors, and tested for association with psychotropic medication and symptom levels.ResultsCXCL16 (p= 0.03) and sIL-2R (p= 7.8 × 10−5) were higher, while sCD14 (p= 0.05) were lower in patients compared to controls after controlling for confounders, with significant differences in SCZ for CXCL16 (p= 0.04) and sIL-2R (p= 1.1 × 10−5). After adjustment for cardiometabolic risk factors higher levels of sIL-2R (p= 0.001) and lower sCD14 (p= 0.002) remained, also in SCZ (sIL-2R,p= 3.0 × 10−4and sCD14,p= 0.01). The adjustment revealed lower ALCAM levels (p= 0.03) in patients. We found no significant associations with psychotropic medication or symptom levels.ConclusionThe results indicate that inflammation, in particular enhanced T cell activation and impaired monocyte activation, are associated with severe mental disorders independent of comorbid cardiometabolic risk factors. This suggests a role of novel pathophysiological mechanisms in severe mental disorders, particularly SCZ. |
| Databáze: | OpenAIRE |
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