Recombinant Factor VIIa: Decreasing Time to Intervention in Coagulopathic Patients With Severe Traumatic Brain Injury
| Autor: | Richard P. Dutton, Deborah M. Stein, Thomas M. Scalea, Mary E. Kramer, Christopher Handley |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Time Factors Traumatic brain injury Factor VIIa Critical Care and Intensive Care Medicine Statistics Nonparametric Head trauma Injury Severity Score Coagulopathy medicine Humans Registries Chi-Square Distribution biology Abbreviated Injury Scale Coagulants business.industry Glasgow Coma Scale medicine.disease Recombinant Proteins Neurosurgical Procedure Treatment Outcome Recombinant factor VIIa Brain Injuries Anesthesia biology.protein Female Surgery business |
| Zdroj: | Journal of Trauma: Injury, Infection & Critical Care. 64:620-628 |
| ISSN: | 0022-5282 |
| Popis: | Background: Treatment of coagulopathy is often needed before neurosurgical intervention in patients with traumatic brain injury (TBI). Typically, this is accomplished with administration of plasma. We hypothesized that the off-label use of recombinant factor VIIa (rFVIIa) to normalize the coagulation profile would allow for earlier intervention than conventional therapy. Methods: The trauma registry was used to identify patients with severe TBI who were admitted during a 4-year period and were coagulopathic at admission (international normalized ratio, INR ≥1.4) and required a neurosurgical procedure. Severe TBI was defined as head abbreviated injury scale (AIS) >3 and admission Glasgow coma score (GCS) |
| Databáze: | OpenAIRE |
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