Long-term stability of physiological signals within fluctuations of brain state under urethane anesthesia

Autor: Rachel Ward-Flanagan, Clayton T. Dickson, Nicholas R G Silver
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Physiology
Hippocampus
Local field potential
Urethane
Urethanes
Rats
Sprague-Dawley
0302 clinical medicine
Heart Rate
Anesthesiology
Medicine and Health Sciences
Anesthesia
Theta Rhythm
0303 health sciences
Multidisciplinary
Neocortex
Chemistry
Pharmaceutics
Respiration
Brain
Drugs
Electroencephalography
Esters
Peripheral
Electrophysiology
medicine.anatomical_structure
Breathing
Physical Sciences
Medicine
Anesthetics
Intravenous
medicine.drug
Research Article
Respiratory rate
Science
Cardiology
Neurophysiology
03 medical and health sciences
Respiratory Rate
Drug Therapy
Heart rate
medicine
Animals
Pain Management
Respiratory Physiology
030304 developmental biology
Anesthetics
Pharmacology
Chemical Compounds
Biology and Life Sciences
Rats
Anesthetic
Sleep
Physiological Processes
Neuroscience
030217 neurology & neurosurgery
Zdroj: PLoS ONE, Vol 16, Iss 10 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258939 (2021)
ISSN: 1932-6203
Popis: Urethane, an acute laboratory anesthetic, produces distinct neurophysiological and physiological effects creating an effective model of the dynamics of natural sleep. As a model of both sleep-like neurophysiological activity and the downstream peripheral function urethane is used to model a variety of physiological and pathophysiological processes. As urethane is typically administered as a single-bolus dose, it is unclear the stability of peripheral physiological functions both within and between brain-states under urethane anesthesia. In this present study, we recorded respiration rate and heart rate concurrently with local field potentials from the neocortex and hippocampus to determine the stability of peripheral physiological functions within and between brain-states under urethane anesthesia. Our data shows electroencephalographic characteristics and breathing rate are remarkable stable over long-term recordings within minor reductions in heart rate on the same time scale. Our findings indicate that the use of urethane to model peripheral physiological functions associated with changing brain states are stable during long duration experiments.
Databáze: OpenAIRE
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