Gossypol suppresses mouse T lymphocytes via inhibition of NFκB, NFAT and AP-1 pathways
| Autor: | Shuang Zhang, Guoren Huang, Gen Li, Zhenning Wang, Jing Lu, Chun-Yu Tong, Ying Xiong, Shuang Guan, Bocui Song |
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| Rok vydání: | 2013 |
| Předmět: |
Male
T cell Immunology Cell Toxicology Plant Roots chemistry.chemical_compound Mice Th2 Cells medicine Immunology and Allergy Animals Pharmacology Gossypium Mice Inbred BALB C biology NFATC Transcription Factors Contraceptive Agents Male Gossypol NF-kappa B NFAT NF-κB General Medicine Th1 Cells Molecular biology Transcription Factor AP-1 medicine.anatomical_structure Biochemistry chemistry Concanavalin A biology.protein Signal transduction CD8 Immunosuppressive Agents Signal Transduction |
| Zdroj: | Immunopharmacology and immunotoxicology. 35(5) |
| ISSN: | 1532-2513 |
| Popis: | Gossypol is a kind of yellow polyphenolic compounds extracted from root stem and seed of the cotton plant. In the present study, we investigated its immunosuppressive mechanism by using BALB/c mouse T lymphocytes in vitro. When mouse splenocytes was incubated with gossypol, the extract effectively suppress the overproduction of the cell stimulated by concanavalin A (ConA) in a dose manner. This inhibitive activity was mainly due to interfering Th1 and Th2 cytokines production and decreasing CD4(+) T cell populations and ratio of CD4(+)/CD8(+). Furthermore, we also showed that signal transduction via NF-κB, NFAT and AP-1 are critical to the ConA-induced T cell activation in mice. The data revealed that gossypol could down-regulate activation of ConA-induced NF-κB, NFAT and AP-1 signal transduction pathways in mouse T lymphocyte. These observations indicated that gossypol exhibited immunosuppressive effects by inhibition T lymphocyte activation in vitro. |
| Databáze: | OpenAIRE |
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