Topical anti-inflammatory activity of palmitoleic acid improves wound healing
| Autor: | Elaine Hatanaka, Eleine Weimann, Rui Curi, José Ricardo Bortolon, Alexandre Dermargos, Gilson Masahiro Murata, Maysa Braga Barros Silva |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Neutrophils Physiology Administration Topical Interleukin-1beta Anti-Inflammatory Agents lcsh:Medicine Pharmacology Pathology and Laboratory Medicine Biochemistry Fatty Acids Monounsaturated RATOS chemistry.chemical_compound White Blood Cells 0302 clinical medicine Endocrinology Animal Cells Immune Physiology Medicine and Health Sciences Palmitoleic acid lcsh:Science Immune Response Skin Innate Immune System Multidisciplinary Fatty Acids Granulation tissue Lipids medicine.anatomical_structure 030220 oncology & carcinogenesis Cytokines medicine.symptom Cellular Types Research Article Wound site Exudate Linoleic acid Immune Cells Immunology Inflammation Linoleic Acid 03 medical and health sciences Signs and Symptoms Diagnostic Medicine Growth Factors Tissue Repair medicine Animals Humans Wound Healing Blood Cells Endocrine Physiology Tumor Necrosis Factor-alpha lcsh:R Biology and Life Sciences Cell Biology Molecular Development Rats 030104 developmental biology chemistry Gene Expression Regulation Immune System lcsh:Q Topical anti-inflammatory Wound healing Physiological Processes Developmental Biology |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP PLoS ONE PLoS ONE, Vol 13, Iss 10, p e0205338 (2018) |
| Popis: | This study investigated the effects of palmitoleic acid on different phases of the healing process. Macroscopic analyses were performed on wounds in rats with or without palmitoleic acid treatment, and the results showed that palmitoleic acid directly hastened wound closure. The topical treatment of wounds with palmitoleic acid resulted in smaller wounds than those observed in the control group. The anti-inflammatory activity of palmitoleic acid may be responsible for healing, especially in the stages of granulation tissue formation and remodelling. Palmitoleic acid modified TNF-α, IL-1β, IL-6, CINC-2α/β, MIP-3α and VEGF-α profiles at the wound site 24, 48, 120, 216 and 288 hours post-wounding. Assays assessing neutrophil migration and exudate formation in sterile inflammatory air pouches revealed that palmitoleic acid had potent anti-inflammatory activity, inhibiting the LPS-induced release of TNF-α (73.14%, p≤0.05), IL-1β (66.19%, p≤0.001), IL-6 (75.19%, p≤0.001), MIP-3α (70.38%, p≤0.05), and l-selectin (16%, p≤0.05). Palmitoleic acid also inhibited LPS-stimulated neutrophil migration. We concluded that palmitoleic acid accelerates wound healing via an anti-inflammatory effect. |
| Databáze: | OpenAIRE |
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